TY - JOUR
T1 - Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction
AU - COVID-CNS Consortium
AU - Wood, Greta K
AU - Sargent, Brendan F
AU - Ahmad, Zain-Ul-Abideen
AU - Tharmaratnam, Kukatharmini
AU - Dunai, Cordelia
AU - Egbe, Franklyn N
AU - Martin, Naomi H
AU - Facer, Bethany
AU - Pendered, Sophie L
AU - Rogers, Henry C
AU - Hübel, Christopher
AU - van Wamelen, Daniel J
AU - Bethlehem, Richard A I
AU - Giunchiglia, Valentina
AU - Hellyer, Peter J
AU - Trender, William
AU - Kalsi, Gursharan
AU - Needham, Edward
AU - Easton, Ava
AU - Jackson, Thomas A
AU - Cunningham, Colm
AU - Upthegrove, Rachel
AU - Pollak, Thomas A
AU - Hotopf, Matthew
AU - Solomon, Tom
AU - Pett, Sarah L
AU - Shaw, Pamela J
AU - Wood, Nicholas
AU - Harrison, Neil A
AU - Miller, Karla L
AU - Jezzard, Peter
AU - Williams, Guy
AU - Duff, Eugene P
AU - Williams, Steven
AU - Zelaya, Fernando
AU - Smith, Stephen M
AU - Keller, Simon
AU - Broome, Matthew
AU - Kingston, Nathalie
AU - Husain, Masud
AU - Vincent, Angela
AU - Bradley, John
AU - Chinnery, Patrick
AU - Menon, David K
AU - Aggleton, John P
AU - Nicholson, Timothy R
AU - Taylor, John-Paul
AU - David, Anthony S
AU - Breen, Gerome
AU - Hampshire, Adam
N1 - © 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2024/9/23
Y1 - 2024/9/23
N2 - The spectrum, pathophysiology and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the 1-year cognitive, serum biomarker and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who required hospitalization, compared with 2,927 normative matched controls. Cognitive deficits were global, associated with elevated brain injury markers and reduced anterior cingulate cortex volume 1 year after COVID-19. Severity of the initial infective insult, postacute psychiatric symptoms and a history of encephalopathy were associated with the greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. Together, these findings support the hypothesis that brain injury in moderate to severe COVID-19 may be immune-mediated, and should guide the development of therapeutic strategies.
AB - The spectrum, pathophysiology and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the 1-year cognitive, serum biomarker and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who required hospitalization, compared with 2,927 normative matched controls. Cognitive deficits were global, associated with elevated brain injury markers and reduced anterior cingulate cortex volume 1 year after COVID-19. Severity of the initial infective insult, postacute psychiatric symptoms and a history of encephalopathy were associated with the greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. Together, these findings support the hypothesis that brain injury in moderate to severe COVID-19 may be immune-mediated, and should guide the development of therapeutic strategies.
UR - http://www.scopus.com/inward/record.url?scp=85208633557&partnerID=8YFLogxK
U2 - 10.1038/s41591-024-03309-8
DO - 10.1038/s41591-024-03309-8
M3 - Article
C2 - 39312956
SN - 1078-8956
JO - Nature Medicine
JF - Nature Medicine
ER -
