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Potent fluoro-oligosaccharide probes of adhesion in Toxoplasmosis

Research output: Contribution to journalArticle

Sarah A. Allman, Henrik H. Jensen, Balakumar Vijayakrishnan, James A. Garnett, Ester Leon, Yan Liu, Daniel C. Anthony, Nicola R. Sibson, Ten Feizi, Stephen Matthews, Benjamin G. Davis

Original languageEnglish
Pages (from-to)2522-2529
Number of pages8
JournalChemBioChem
Volume10
Issue number15
DOIs
Publication statusPublished - 12 Oct 2009

King's Authors

Abstract

Unnatural, NMR- and MRI-active fluorinated sugar probes, designed and synthesised to bind to the pathogenic protein TgMIC1 from Toxoplasma gondii, were found to display binding potency equal to and above that of the natural ligand. Dissection of the binding mechanism and modes, including the first X-ray crystal structures of a fluoro-oligosaccharide bound to a lectin, demonstrate that it is possible to create effective fluorinated probe ligands for the study of, and perhaps intervention in, sugar-protein binding events.

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