@article{130479a6ec6248a7aab592ea8d379157,
title = "PPI-Induced Changes in Plasma Metabolite Levels Influence Total Hip Bone Mineral Density in a UK Cohort",
abstract = "Proton pump inhibitors (PPIs) are among the most used drugs in the UK. PPI use has been associated with decreased bone mineral density (BMD) and increased fracture risk, although these results have been inconsistent. We hypothesized that PPI could modulate BMD by altering gut and/or host systemic metabolic environments. Using data from more than 5000 British male and female individuals, we confirmed that PPI use is associated with decreased lumbar spine and total hip BMD. This effect was not mediated through the gut microbiome. We suggest here that PPI use may influence total hip BMD, both directly and indirectly, via plasma metabolites involved in the sex hormone pathway.",
keywords = "BONE MINERAL DENSITY, GUT METABOLOME, GUT MICROBIOME, HOST METABOLOME, PROTON PUMP INHIBITORS",
author = "Xinyuan Zhang and Adewale Adebayo and Dongmeng Wang and Yasrab Raza and Max Tomlinson and Hannah Dooley and Ruth Bowyer and Kerrin Small and Claire Steves and Tim Spector and Emma Duncan and Alessia Visconti and Mario Falchi",
note = "Funding Information: TwinsUK is funded by the Wellcome Trust, Medical Research Council, Versus Arthritis, European Union Horizon 2020, Chronic Disease Research Foundation (CDRF), Zoe Ltd and the National Institute for Health Research (NIHR) Clinical Research Network (CRN) and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London. XZ and DW are funded by King's-China Scholarship Council PhD Scholarship. YR and MT are funded by National Institute for Health and Care Research (NIHR) and Biomedical Research Centre (BRC). Funding Information: TwinsUK is funded by the Wellcome Trust, Medical Research Council, Versus Arthritis, European Union Horizon 2020, Chronic Disease Research Foundation (CDRF), Zoe Ltd and the National Institute for Health Research (NIHR) Clinical Research Network (CRN) and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London. XZ and DW are funded by King's‐China Scholarship Council PhD Scholarship. YR and MT are funded by National Institute for Health and Care Research (NIHR) and Biomedical Research Centre (BRC). Publisher Copyright: {\textcopyright} 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).",
year = "2023",
month = feb,
doi = "10.1002/jbmr.4754",
language = "English",
volume = "38",
pages = "326--334",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "2",
}
