Pain research continues to face the challenge of poor translatability of pre-clinical studies. In this short primer, we are summarizing the possible causes, with an emphasis on practical and constructive solutions. In particular, we stress the importance of increased heterogeneity in animal studies; formal or informal pre-registration to combat publication bias; and increased statistical training in order to help pre-clinical scientists appreciate the usefulness of available experimental design and reporting guidelines.

Original languageEnglish
Pages (from-to)38-42
Number of pages5
JournalBrain, Behavior, and Immunity
Publication statusPublished - Jan 2024


  • Animals
  • Reproducibility of Results
  • Research Design
  • Pain


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