Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Mohamed Abdulkadir; Jay A. Tischfield; Robert A. King; Thomas V. Fernandez; Lawrence W. Brown; Keun Ah Cheon; Barbara J. Coffey; Sebastian F T M de Bruijn; Lonneke Elzerman; Blanca Garcia-Delgar; Donald L. Gilbert; Dorothy E. Grice; Julie Hagstrøm; Tamasine Hedderly; Isobel Heyman; Hyun Ju Hong; Chaim Huyser; Laura Ibanez-Gomez; Young Key Kim; Young Shin Kim; Yun Joo Koh; Sodahm Kook; Samuel Kuperman; Andreas Lamerz; Bennett Leventhal; Andrea G. Ludolph; Marcos Madruga-Garrido; Athanasios Maras; Marieke D. Messchendorp; Pablo Mir; Astrid Morer; Alexander Münchau; Tara L. Murphy; Thaïra J C Openneer; Kerstin J. Plessen; Judith J G Rath; Veit Roessner; Odette Fründt; Eun Young Shin; Deborah A. Sival; Dong Ho Song; Jungeun Song; Anne Marie Stolte; Jennifer Tübing; Els van den Ban; Frank Visscher; Sina Wanderer; Martin Woods; Samuel H. Zinner; Matthew W. State; Gary A. Heiman; Pieter J. Hoekstra; Andrea Dietrich

doi:10.1016/j.jpsychires.2016.07.017

Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Mohamed Abdulkadir^*, Jay A. Tischfield, Robert A. King, Thomas V. Fernandez, Lawrence W. Brown, Keun Ah Cheon, Barbara J. Coffey, Sebastian F T M de Bruijn, Lonneke Elzerman, Blanca Garcia-Delgar, Donald L. Gilbert, Dorothy E. Grice, Julie Hagstrøm, Tamasine Hedderly, Isobel Heyman, Hyun Ju Hong, Chaim Huyser, Laura Ibanez-Gomez, Young Key Kim, Young Shin KimYun Joo Koh, Sodahm Kook, Samuel Kuperman, Andreas Lamerz, Bennett Leventhal, Andrea G. Ludolph, Marcos Madruga-Garrido, Athanasios Maras, Marieke D. Messchendorp, Pablo Mir, Astrid Morer, Alexander Münchau, Tara L. Murphy, Thaïra J C Openneer, Kerstin J. Plessen, Judith J G Rath, Veit Roessner, Odette Fründt, Eun Young Shin, Deborah A. Sival, Dong Ho Song, Jungeun Song, Anne Marie Stolte, Jennifer Tübing, Els van den Ban, Frank Visscher, Sina Wanderer, Martin Woods, Samuel H. Zinner, Matthew W. State, Gary A. Heiman, Pieter J. Hoekstra, Andrea Dietrich

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention–deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.

Original language	English
Pages (from-to)	126-135
Number of pages	10
Journal	Journal of psychiatric research
Volume	82
Early online date	22 Jul 2016
DOIs	https://doi.org/10.1016/j.jpsychires.2016.07.017
Publication status	Published - 1 Nov 2016

Keywords

Attention-deficit hyperactivity disorder
Delivery
Obsessive-compulsive disorder
Pregnancy
Prenatal
Tourette syndrome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jpsychires.2016.07.017

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Abdulkadir, M., Tischfield, J. A., King, R. A., Fernandez, T. V., Brown, L. W., Cheon, K. A., Coffey, B. J., de Bruijn, S. F. T. M., Elzerman, L., Garcia-Delgar, B., Gilbert, D. L., Grice, D. E., Hagstrøm, J., Hedderly, T., Heyman, I., Hong, H. J., Huyser, C., Ibanez-Gomez, L., Kim, Y. K., ... Dietrich, A. (2016). Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder. Journal of psychiatric research, 82, 126-135. https://doi.org/10.1016/j.jpsychires.2016.07.017

@article{cd12a571b4704996bc819e53083fc492,

title = "Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder",

abstract = "Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention–deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.",

keywords = "Attention-deficit hyperactivity disorder, Delivery, Obsessive-compulsive disorder, Pregnancy, Prenatal, Tourette syndrome",

author = "Mohamed Abdulkadir and Tischfield, {Jay A.} and King, {Robert A.} and Fernandez, {Thomas V.} and Brown, {Lawrence W.} and Cheon, {Keun Ah} and Coffey, {Barbara J.} and {de Bruijn}, {Sebastian F T M} and Lonneke Elzerman and Blanca Garcia-Delgar and Gilbert, {Donald L.} and Grice, {Dorothy E.} and Julie Hagstr{\o}m and Tamasine Hedderly and Isobel Heyman and Hong, {Hyun Ju} and Chaim Huyser and Laura Ibanez-Gomez and Kim, {Young Key} and Kim, {Young Shin} and Koh, {Yun Joo} and Sodahm Kook and Samuel Kuperman and Andreas Lamerz and Bennett Leventhal and Ludolph, {Andrea G.} and Marcos Madruga-Garrido and Athanasios Maras and Messchendorp, {Marieke D.} and Pablo Mir and Astrid Morer and Alexander M{\"u}nchau and Murphy, {Tara L.} and Openneer, {Tha{\"i}ra J C} and Plessen, {Kerstin J.} and Rath, {Judith J G} and Veit Roessner and Odette Fr{\"u}ndt and Shin, {Eun Young} and Sival, {Deborah A.} and Song, {Dong Ho} and Jungeun Song and Stolte, {Anne Marie} and Jennifer T{\"u}bing and {van den Ban}, Els and Frank Visscher and Sina Wanderer and Martin Woods and Zinner, {Samuel H.} and State, {Matthew W.} and Heiman, {Gary A.} and Hoekstra, {Pieter J.} and Andrea Dietrich",

year = "2016",

month = nov,

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doi = "10.1016/j.jpsychires.2016.07.017",

language = "English",

volume = "82",

pages = "126--135",

journal = "Journal of psychiatric research",

issn = "0022-3956",

publisher = "Elsevier",

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Abdulkadir, M, Tischfield, JA, King, RA, Fernandez, TV, Brown, LW, Cheon, KA, Coffey, BJ, de Bruijn, SFTM, Elzerman, L, Garcia-Delgar, B, Gilbert, DL, Grice, DE, Hagstrøm, J, Hedderly, T, Heyman, I, Hong, HJ, Huyser, C, Ibanez-Gomez, L, Kim, YK, Kim, YS, Koh, YJ, Kook, S, Kuperman, S, Lamerz, A, Leventhal, B, Ludolph, AG, Madruga-Garrido, M, Maras, A, Messchendorp, MD, Mir, P, Morer, A, Münchau, A, Murphy, TL, Openneer, TJC, Plessen, KJ, Rath, JJG, Roessner, V, Fründt, O, Shin, EY, Sival, DA, Song, DH, Song, J, Stolte, AM, Tübing, J, van den Ban, E, Visscher, F, Wanderer, S, Woods, M, Zinner, SH, State, MW, Heiman, GA, Hoekstra, PJ & Dietrich, A 2016, 'Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder', Journal of psychiatric research, vol. 82, pp. 126-135. https://doi.org/10.1016/j.jpsychires.2016.07.017

TY - JOUR

T1 - Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

AU - Abdulkadir, Mohamed

AU - Tischfield, Jay A.

AU - King, Robert A.

AU - Fernandez, Thomas V.

AU - Brown, Lawrence W.

AU - Cheon, Keun Ah

AU - Coffey, Barbara J.

AU - de Bruijn, Sebastian F T M

AU - Elzerman, Lonneke

AU - Garcia-Delgar, Blanca

AU - Gilbert, Donald L.

AU - Grice, Dorothy E.

AU - Hagstrøm, Julie

AU - Hedderly, Tamasine

AU - Heyman, Isobel

AU - Hong, Hyun Ju

AU - Huyser, Chaim

AU - Ibanez-Gomez, Laura

AU - Kim, Young Key

AU - Kim, Young Shin

AU - Koh, Yun Joo

AU - Kook, Sodahm

AU - Kuperman, Samuel

AU - Lamerz, Andreas

AU - Leventhal, Bennett

AU - Ludolph, Andrea G.

AU - Madruga-Garrido, Marcos

AU - Maras, Athanasios

AU - Messchendorp, Marieke D.

AU - Mir, Pablo

AU - Morer, Astrid

AU - Münchau, Alexander

AU - Murphy, Tara L.

AU - Openneer, Thaïra J C

AU - Plessen, Kerstin J.

AU - Rath, Judith J G

AU - Roessner, Veit

AU - Fründt, Odette

AU - Shin, Eun Young

AU - Sival, Deborah A.

AU - Song, Dong Ho

AU - Song, Jungeun

AU - Stolte, Anne Marie

AU - Tübing, Jennifer

AU - van den Ban, Els

AU - Visscher, Frank

AU - Wanderer, Sina

AU - Woods, Martin

AU - Zinner, Samuel H.

AU - State, Matthew W.

AU - Heiman, Gary A.

AU - Hoekstra, Pieter J.

AU - Dietrich, Andrea

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention–deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.

AB - Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention–deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.

KW - Attention-deficit hyperactivity disorder

KW - Delivery

KW - Obsessive-compulsive disorder

KW - Pregnancy

KW - Prenatal

KW - Tourette syndrome

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U2 - 10.1016/j.jpsychires.2016.07.017

DO - 10.1016/j.jpsychires.2016.07.017

M3 - Article

AN - SCOPUS:84980332253

SN - 0022-3956

VL - 82

SP - 126

EP - 135

JO - Journal of psychiatric research

JF - Journal of psychiatric research

ER -

Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Abstract

Keywords

UN SDGs

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