Pre-morbid Conduct Disorder symptoms are associated with cannabis use among individuals with a first episode of psychosis

Charlotte P. Malcolm; Marco M. Picchioni; Marta DiForti; Gisela Sugranyes; Elizabeth Cooke; Candice Joseph; Grant McQueen; Alessandra Paparelli; Simona Stilo; Jennifer O'Connor; Craig Morgan; Robin M. Murray; Sheilagh Hodgins

doi:10.1016/j.schres.2010.11.025

Pre-morbid Conduct Disorder symptoms are associated with cannabis use among individuals with a first episode of psychosis

Charlotte P. Malcolm, Marco M. Picchioni, Marta DiForti, Gisela Sugranyes, Elizabeth Cooke, Candice Joseph, Grant McQueen, Alessandra Paparelli, Simona Stilo, Jennifer O'Connor, Craig Morgan, Robin M. Murray, Sheilagh Hodgins

Kings Coll London, Inst Psychiat

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Background: Early cannabis use has consistently been associated with an increased risk for the later development of psychosis. Studies suggest that Conduct Disorder (CD) is more common amongst young people who later go on to develop psychosis. CD has been associated with greater and earlier cannabis use in general population samples. Based on this evidence, we hypothesised that among patients experiencing their first episode of psychosis, the presence of CD symptoms prior to age 15 would be associated with cannabis use. Method: 102 patients experiencing a first episode of psychosis were interviewed to assess CD symptoms prior to age 15 and use of cannabis and other substances. Results: The number of CD symptoms was significantly associated with lifetime cannabis use (odds ratio = 5.41 (1.76-16.57), p = 0.03) and with first use of cannabis before age 14 (odds ratio = 1.46 (1.12-1.92), p = 0.006), after controlling for stimulant/hallucinogen use and level of education. Conclusions: Among patients experiencing a first episode of psychosis, CD symptoms were significantly associated with use of cannabis and with use by age 14. Among individuals vulnerable for psychosis, CD symptoms may independently increase the likelihood of cannabis use which in turn increases the risk of psychosis.

Original language	English
Pages (from-to)	81 - 86
Number of pages	6
Journal	Schizophrenia Research
Volume	126
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2010.11.025
Publication status	Published - Mar 2011

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Malcolm, C. P., Picchioni, M. M., DiForti, M., Sugranyes, G., Cooke, E., Joseph, C., McQueen, G., Paparelli, A., Stilo, S., O'Connor, J., Morgan, C., Murray, R. M., & Hodgins, S. (2011). Pre-morbid Conduct Disorder symptoms are associated with cannabis use among individuals with a first episode of psychosis. Schizophrenia Research, 126(1-3), 81 - 86. https://doi.org/10.1016/j.schres.2010.11.025

@article{69a082aac43f48fc98c4d19c46dba0ec,

title = "Pre-morbid Conduct Disorder symptoms are associated with cannabis use among individuals with a first episode of psychosis",

abstract = "Background: Early cannabis use has consistently been associated with an increased risk for the later development of psychosis. Studies suggest that Conduct Disorder (CD) is more common amongst young people who later go on to develop psychosis. CD has been associated with greater and earlier cannabis use in general population samples. Based on this evidence, we hypothesised that among patients experiencing their first episode of psychosis, the presence of CD symptoms prior to age 15 would be associated with cannabis use. Method: 102 patients experiencing a first episode of psychosis were interviewed to assess CD symptoms prior to age 15 and use of cannabis and other substances. Results: The number of CD symptoms was significantly associated with lifetime cannabis use (odds ratio = 5.41 (1.76-16.57), p = 0.03) and with first use of cannabis before age 14 (odds ratio = 1.46 (1.12-1.92), p = 0.006), after controlling for stimulant/hallucinogen use and level of education. Conclusions: Among patients experiencing a first episode of psychosis, CD symptoms were significantly associated with use of cannabis and with use by age 14. Among individuals vulnerable for psychosis, CD symptoms may independently increase the likelihood of cannabis use which in turn increases the risk of psychosis.",

author = "Malcolm, {Charlotte P.} and Picchioni, {Marco M.} and Marta DiForti and Gisela Sugranyes and Elizabeth Cooke and Candice Joseph and Grant McQueen and Alessandra Paparelli and Simona Stilo and Jennifer O'Connor and Craig Morgan and Murray, {Robin M.} and Sheilagh Hodgins",

year = "2011",

month = mar,

doi = "10.1016/j.schres.2010.11.025",

language = "English",

volume = "126",

pages = "81 -- 86",

journal = "Schizophrenia Research",

issn = "1573-2509",

publisher = "Elsevier",

number = "1-3",

}

Malcolm, CP , Picchioni, MM , DiForti, M, Sugranyes, G, Cooke, E, Joseph, C, McQueen, G, Paparelli, A, Stilo, S, O'Connor, J , Morgan, C , Murray, RM & Hodgins, S 2011, 'Pre-morbid Conduct Disorder symptoms are associated with cannabis use among individuals with a first episode of psychosis', Schizophrenia Research, vol. 126, no. 1-3, pp. 81 - 86. https://doi.org/10.1016/j.schres.2010.11.025

TY - JOUR

T1 - Pre-morbid Conduct Disorder symptoms are associated with cannabis use among individuals with a first episode of psychosis

AU - Malcolm, Charlotte P.

AU - Picchioni, Marco M.

AU - DiForti, Marta

AU - Sugranyes, Gisela

AU - Cooke, Elizabeth

AU - Joseph, Candice

AU - McQueen, Grant

AU - Paparelli, Alessandra

AU - Stilo, Simona

AU - O'Connor, Jennifer

AU - Morgan, Craig

AU - Murray, Robin M.

AU - Hodgins, Sheilagh

PY - 2011/3

Y1 - 2011/3

N2 - Background: Early cannabis use has consistently been associated with an increased risk for the later development of psychosis. Studies suggest that Conduct Disorder (CD) is more common amongst young people who later go on to develop psychosis. CD has been associated with greater and earlier cannabis use in general population samples. Based on this evidence, we hypothesised that among patients experiencing their first episode of psychosis, the presence of CD symptoms prior to age 15 would be associated with cannabis use. Method: 102 patients experiencing a first episode of psychosis were interviewed to assess CD symptoms prior to age 15 and use of cannabis and other substances. Results: The number of CD symptoms was significantly associated with lifetime cannabis use (odds ratio = 5.41 (1.76-16.57), p = 0.03) and with first use of cannabis before age 14 (odds ratio = 1.46 (1.12-1.92), p = 0.006), after controlling for stimulant/hallucinogen use and level of education. Conclusions: Among patients experiencing a first episode of psychosis, CD symptoms were significantly associated with use of cannabis and with use by age 14. Among individuals vulnerable for psychosis, CD symptoms may independently increase the likelihood of cannabis use which in turn increases the risk of psychosis.

AB - Background: Early cannabis use has consistently been associated with an increased risk for the later development of psychosis. Studies suggest that Conduct Disorder (CD) is more common amongst young people who later go on to develop psychosis. CD has been associated with greater and earlier cannabis use in general population samples. Based on this evidence, we hypothesised that among patients experiencing their first episode of psychosis, the presence of CD symptoms prior to age 15 would be associated with cannabis use. Method: 102 patients experiencing a first episode of psychosis were interviewed to assess CD symptoms prior to age 15 and use of cannabis and other substances. Results: The number of CD symptoms was significantly associated with lifetime cannabis use (odds ratio = 5.41 (1.76-16.57), p = 0.03) and with first use of cannabis before age 14 (odds ratio = 1.46 (1.12-1.92), p = 0.006), after controlling for stimulant/hallucinogen use and level of education. Conclusions: Among patients experiencing a first episode of psychosis, CD symptoms were significantly associated with use of cannabis and with use by age 14. Among individuals vulnerable for psychosis, CD symptoms may independently increase the likelihood of cannabis use which in turn increases the risk of psychosis.

U2 - 10.1016/j.schres.2010.11.025

DO - 10.1016/j.schres.2010.11.025

M3 - Article

SN - 1573-2509

VL - 126

SP - 81

EP - 86

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -

Pre-morbid Conduct Disorder symptoms are associated with cannabis use among individuals with a first episode of psychosis

Abstract

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