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Prediabetes and diabetes in relation to risk of gastric adenocarcinoma

Research output: Contribution to journalArticle

Jiaojiao Zheng, Martin Rutegård, Giola Santoni, Bengt Wallner, Ingegerd Johansson, Malin Sund, Shao Hua Xie, Jesper Lagergren

Original languageEnglish
Pages (from-to)1147-1152
Number of pages6
JournalBritish Journal of Cancer
Volume120
Issue number12
Early online date7 May 2019
DOIs
Accepted/In press18 Apr 2019
E-pub ahead of print7 May 2019
Published11 Jun 2019

King's Authors

Abstract

Background: 

Whether prediabetes or diabetes increases the risk of gastric adenocarcinoma is not clear. 

Methods: 

This cohort study included 111,198 participants in the Northern Swedish Health and Disease Study. The participants were followed up from November 1985 to April 2017. The exposure to prediabetes or diabetes was assessed by oral glucose tolerance tests and self-reports. The incidence of the outcome gastric adenocarcinoma was identified from the Swedish Cancer Registry. Multivariable Cox regressions were used to analyse the associations between prediabetes or diabetes and the risk of gastric adenocarcinoma, providing hazard ratios (HR) with 95% confidence intervals (CI), with adjustment for sex, age, calendar year, body mass index, tobacco smoking and education level. 

Results: 

Compared with normoglycaemic participants, the risk of gastric adenocarcinoma was not increased among participants with prediabetes (HR 1.07, 95% CI 0.79–1.44), diabetes (HR 0.77, 95% CI 0.46–1.29) or any of these exposures (HR 0.96, 95% CI 0.73–1.27). No associations were identified between prediabetes or diabetes and the risk of gastric adenocarcinoma in stratified analyses or in analyses separating cardia and non-cardia gastric adenocarcinoma. 

Conclusions: 

This study does not support the hypothesis that prediabetes or diabetes increases the risk of gastric adenocarcinoma.

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