Prediabetes remission to reduce the global burden of type 2 diabetes

Leontine Sandforth; Stephanie Kullmann; Arvid Sandforth; Andreas Fritsche; Reiner Jumpertz-von Schwartzenberg; Norbert Stefan; Andreas L. Birkenfeld

doi:10.1016/j.tem.2025.01.004

Prediabetes remission to reduce the global burden of type 2 diabetes

Leontine Sandforth, Stephanie Kullmann, Arvid Sandforth, Andreas Fritsche, Reiner Jumpertz-von Schwartzenberg, Norbert Stefan, Andreas L. Birkenfeld^*

^*Corresponding author for this work

SCMMS Denmark Hill

Research output: Contribution to journal › Review article › peer-review

Abstract

Prediabetes is a highly prevalent and increasingly common condition affecting a significant proportion of the global population. The heterogeneous nature of prediabetes presents a challenge in identifying individuals who particularly benefit from lifestyle or other therapeutic interventions aiming at preventing type 2 diabetes (T2D) and associated comorbidities. The phenotypic characteristics of individuals at risk for diabetes are associated with both specific risk profiles for progression and a differential potential to facilitate prediabetes remission and reduce the risk of future T2D. This review examines the current definition and global prevalence of prediabetes and evaluates the potential of prediabetes remission to reduce the alarming increase in the global burden of T2D.

Original language	English
Journal	TRENDS IN ENDOCRINOLOGY AND METABOLISM
DOIs	https://doi.org/10.1016/j.tem.2025.01.004
Publication status	Accepted/In press - 2025

Keywords

normal glucose tolerance
obesity
prediabetes
remission
type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tem.2025.01.004

Cite this

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title = "Prediabetes remission to reduce the global burden of type 2 diabetes",

abstract = "Prediabetes is a highly prevalent and increasingly common condition affecting a significant proportion of the global population. The heterogeneous nature of prediabetes presents a challenge in identifying individuals who particularly benefit from lifestyle or other therapeutic interventions aiming at preventing type 2 diabetes (T2D) and associated comorbidities. The phenotypic characteristics of individuals at risk for diabetes are associated with both specific risk profiles for progression and a differential potential to facilitate prediabetes remission and reduce the risk of future T2D. This review examines the current definition and global prevalence of prediabetes and evaluates the potential of prediabetes remission to reduce the alarming increase in the global burden of T2D.",

keywords = "normal glucose tolerance, obesity, prediabetes, remission, type 2 diabetes",

author = "Leontine Sandforth and Stephanie Kullmann and Arvid Sandforth and Andreas Fritsche and {Jumpertz-von Schwartzenberg}, Reiner and Norbert Stefan and Birkenfeld, {Andreas L.}",

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T1 - Prediabetes remission to reduce the global burden of type 2 diabetes

AU - Sandforth, Leontine

AU - Kullmann, Stephanie

AU - Sandforth, Arvid

AU - Fritsche, Andreas

AU - Jumpertz-von Schwartzenberg, Reiner

AU - Stefan, Norbert

AU - Birkenfeld, Andreas L.

PY - 2025

Y1 - 2025

N2 - Prediabetes is a highly prevalent and increasingly common condition affecting a significant proportion of the global population. The heterogeneous nature of prediabetes presents a challenge in identifying individuals who particularly benefit from lifestyle or other therapeutic interventions aiming at preventing type 2 diabetes (T2D) and associated comorbidities. The phenotypic characteristics of individuals at risk for diabetes are associated with both specific risk profiles for progression and a differential potential to facilitate prediabetes remission and reduce the risk of future T2D. This review examines the current definition and global prevalence of prediabetes and evaluates the potential of prediabetes remission to reduce the alarming increase in the global burden of T2D.

AB - Prediabetes is a highly prevalent and increasingly common condition affecting a significant proportion of the global population. The heterogeneous nature of prediabetes presents a challenge in identifying individuals who particularly benefit from lifestyle or other therapeutic interventions aiming at preventing type 2 diabetes (T2D) and associated comorbidities. The phenotypic characteristics of individuals at risk for diabetes are associated with both specific risk profiles for progression and a differential potential to facilitate prediabetes remission and reduce the risk of future T2D. This review examines the current definition and global prevalence of prediabetes and evaluates the potential of prediabetes remission to reduce the alarming increase in the global burden of T2D.

KW - normal glucose tolerance

KW - obesity

KW - prediabetes

KW - remission

KW - type 2 diabetes

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DO - 10.1016/j.tem.2025.01.004

M3 - Review article

AN - SCOPUS:85217956303

SN - 1043-2760

JO - TRENDS IN ENDOCRINOLOGY AND METABOLISM

JF - TRENDS IN ENDOCRINOLOGY AND METABOLISM

ER -

Prediabetes remission to reduce the global burden of type 2 diabetes

Abstract

Keywords

UN SDGs

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