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Prediagnostic circulating levels of sex hormones and survival in esophageal adenocarcinoma

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Prediagnostic circulating levels of sex hormones and survival in esophageal adenocarcinoma. / Xie, Shao Hua; Ness-Jensen, Eivind; Langseth, Hilde; Gislefoss, Randi E.; Mattsson, Fredrik; Lagergren, Jesper.

In: International Journal of Cancer, Vol. 148, No. 4, 15.02.2021, p. 905-913.

Research output: Contribution to journalArticlepeer-review

Harvard

Xie, SH, Ness-Jensen, E, Langseth, H, Gislefoss, RE, Mattsson, F & Lagergren, J 2021, 'Prediagnostic circulating levels of sex hormones and survival in esophageal adenocarcinoma', International Journal of Cancer, vol. 148, no. 4, pp. 905-913. https://doi.org/10.1002/ijc.33285

APA

Xie, S. H., Ness-Jensen, E., Langseth, H., Gislefoss, R. E., Mattsson, F., & Lagergren, J. (2021). Prediagnostic circulating levels of sex hormones and survival in esophageal adenocarcinoma. International Journal of Cancer, 148(4), 905-913. https://doi.org/10.1002/ijc.33285

Vancouver

Xie SH, Ness-Jensen E, Langseth H, Gislefoss RE, Mattsson F, Lagergren J. Prediagnostic circulating levels of sex hormones and survival in esophageal adenocarcinoma. International Journal of Cancer. 2021 Feb 15;148(4):905-913. https://doi.org/10.1002/ijc.33285

Author

Xie, Shao Hua ; Ness-Jensen, Eivind ; Langseth, Hilde ; Gislefoss, Randi E. ; Mattsson, Fredrik ; Lagergren, Jesper. / Prediagnostic circulating levels of sex hormones and survival in esophageal adenocarcinoma. In: International Journal of Cancer. 2021 ; Vol. 148, No. 4. pp. 905-913.

Bibtex Download

@article{8394db19649947d2b532e51956cb29f9,
title = "Prediagnostic circulating levels of sex hormones and survival in esophageal adenocarcinoma",
abstract = "Sex hormonal differences may contribute to the strong male predominance in esophageal adenocarcinoma (EAC), but whether sex hormone levels influence survival in EAC is unstudied. Our study aimed to assess associations between prediagnostic sex hormone levels and survival in EAC. In a population-based cohort study, 244 male EAC patients from the Janus Serum Bank Cohort in Norway were followed up through 2018. Associations between prediagnostic serum levels of 12 sex hormone measures and disease-specific mortality were assessed using multivariable Cox regression, providing hazard ratios (HR) with 95% confidence intervals (CI) adjusted for age, calendar year, body mass index, tobacco smoking, physical activity and surgical resection. Higher levels of sex hormone-binding globulin (SHBG) indicated decreased disease-specific mortality (HR 0.68, 95% CI 0.44-1.07, highest vs lowest tertile). In stratified analyses by surgery, such associations remained in nonoperated patients (HR 0.58, 95% CI 0.35-0.96, highest vs lowest tertile), but not in operated patients. Higher levels of follicle-stimulating hormone (FSH) were associated with increased disease-specific mortality in an exposure-response pattern; HRs for the middle and highest tertiles vs the lowest tertile were 1.35 (95% CI 0.89-2.05) and 1.61 (95% CI 1.06-2.43), respectively. No clear associations were observed with serum levels of dehydroepiandrosterone sulfate, luteinizing hormone, prolactin, testosterone, 17-OH-progesterone, progesterone, estradiol, androstenedione, testosterone:estradiol ratio or free testosterone index. These findings suggest that higher endogenous levels of SHBG and lower levels of FSH may increase the survival in EAC. The other 10 examined sex hormone measures may not influence the survival.",
keywords = "adenocarcinoma, esophageal neoplasms, gonadal steroid hormones, mortality, prognosis",
author = "Xie, {Shao Hua} and Eivind Ness-Jensen and Hilde Langseth and Gislefoss, {Randi E.} and Fredrik Mattsson and Jesper Lagergren",
note = "Funding Information: This work was supported by Cancer Research UK (grant number C51246/A26163). The sponsors had no role in the study design, the collection, analysis, and interpretation of data, or the writing of the manuscript. Publisher Copyright: {\textcopyright} 2020 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of Union for International Cancer Control. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = feb,
day = "15",
doi = "10.1002/ijc.33285",
language = "English",
volume = "148",
pages = "905--913",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "John Wiley & Sons, Ltd",
number = "4",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Prediagnostic circulating levels of sex hormones and survival in esophageal adenocarcinoma

AU - Xie, Shao Hua

AU - Ness-Jensen, Eivind

AU - Langseth, Hilde

AU - Gislefoss, Randi E.

AU - Mattsson, Fredrik

AU - Lagergren, Jesper

N1 - Funding Information: This work was supported by Cancer Research UK (grant number C51246/A26163). The sponsors had no role in the study design, the collection, analysis, and interpretation of data, or the writing of the manuscript. Publisher Copyright: © 2020 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of Union for International Cancer Control. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/2/15

Y1 - 2021/2/15

N2 - Sex hormonal differences may contribute to the strong male predominance in esophageal adenocarcinoma (EAC), but whether sex hormone levels influence survival in EAC is unstudied. Our study aimed to assess associations between prediagnostic sex hormone levels and survival in EAC. In a population-based cohort study, 244 male EAC patients from the Janus Serum Bank Cohort in Norway were followed up through 2018. Associations between prediagnostic serum levels of 12 sex hormone measures and disease-specific mortality were assessed using multivariable Cox regression, providing hazard ratios (HR) with 95% confidence intervals (CI) adjusted for age, calendar year, body mass index, tobacco smoking, physical activity and surgical resection. Higher levels of sex hormone-binding globulin (SHBG) indicated decreased disease-specific mortality (HR 0.68, 95% CI 0.44-1.07, highest vs lowest tertile). In stratified analyses by surgery, such associations remained in nonoperated patients (HR 0.58, 95% CI 0.35-0.96, highest vs lowest tertile), but not in operated patients. Higher levels of follicle-stimulating hormone (FSH) were associated with increased disease-specific mortality in an exposure-response pattern; HRs for the middle and highest tertiles vs the lowest tertile were 1.35 (95% CI 0.89-2.05) and 1.61 (95% CI 1.06-2.43), respectively. No clear associations were observed with serum levels of dehydroepiandrosterone sulfate, luteinizing hormone, prolactin, testosterone, 17-OH-progesterone, progesterone, estradiol, androstenedione, testosterone:estradiol ratio or free testosterone index. These findings suggest that higher endogenous levels of SHBG and lower levels of FSH may increase the survival in EAC. The other 10 examined sex hormone measures may not influence the survival.

AB - Sex hormonal differences may contribute to the strong male predominance in esophageal adenocarcinoma (EAC), but whether sex hormone levels influence survival in EAC is unstudied. Our study aimed to assess associations between prediagnostic sex hormone levels and survival in EAC. In a population-based cohort study, 244 male EAC patients from the Janus Serum Bank Cohort in Norway were followed up through 2018. Associations between prediagnostic serum levels of 12 sex hormone measures and disease-specific mortality were assessed using multivariable Cox regression, providing hazard ratios (HR) with 95% confidence intervals (CI) adjusted for age, calendar year, body mass index, tobacco smoking, physical activity and surgical resection. Higher levels of sex hormone-binding globulin (SHBG) indicated decreased disease-specific mortality (HR 0.68, 95% CI 0.44-1.07, highest vs lowest tertile). In stratified analyses by surgery, such associations remained in nonoperated patients (HR 0.58, 95% CI 0.35-0.96, highest vs lowest tertile), but not in operated patients. Higher levels of follicle-stimulating hormone (FSH) were associated with increased disease-specific mortality in an exposure-response pattern; HRs for the middle and highest tertiles vs the lowest tertile were 1.35 (95% CI 0.89-2.05) and 1.61 (95% CI 1.06-2.43), respectively. No clear associations were observed with serum levels of dehydroepiandrosterone sulfate, luteinizing hormone, prolactin, testosterone, 17-OH-progesterone, progesterone, estradiol, androstenedione, testosterone:estradiol ratio or free testosterone index. These findings suggest that higher endogenous levels of SHBG and lower levels of FSH may increase the survival in EAC. The other 10 examined sex hormone measures may not influence the survival.

KW - adenocarcinoma

KW - esophageal neoplasms

KW - gonadal steroid hormones

KW - mortality

KW - prognosis

UR - http://www.scopus.com/inward/record.url?scp=85091298657&partnerID=8YFLogxK

U2 - 10.1002/ijc.33285

DO - 10.1002/ijc.33285

M3 - Article

C2 - 32895915

AN - SCOPUS:85091298657

VL - 148

SP - 905

EP - 913

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 4

ER -

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