Predicting clinical response in people at ultra-high risk of psychosis: A systematic and quantitative review

Andrea Mechelli; Diana Prata; Charles Kefford; Shitij Kapur

doi:10.1016/j.drudis.2015.03.003

Predicting clinical response in people at ultra-high risk of psychosis: A systematic and quantitative review

Andrea Mechelli^*, Diana Prata, Charles Kefford, Shitij Kapur

^*Corresponding author for this work

King's College London

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

People at ultra-high risk (UHR) of psychosis have ~30% chance of developing the illness within two years. A range of pharmacological and psychosocial interventions are now available but there is great individual variation in clinical response. Here we examine the evidence for clinically applicable predictors of clinical response in people at UHR of psychosis. We report that currently there are no reliable predictive markers that can be used to optimise treatment. We argue that there is an urgent need for a better understanding of why some people at UHR of psychosis benefit from a certain treatment whereas others do not. This information will help clinicians make more-effective treatment decisions, and improve long-term clinical outcomes in this population.

Original language	English
Pages (from-to)	924-927
Number of pages	4
Journal	DRUG DISCOVERY TODAY
Volume	20
Issue number	8
Early online date	18 Mar 2015
DOIs	https://doi.org/10.1016/j.drudis.2015.03.003
Publication status	Published - 1 Aug 2015

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Predicting clinical response in people at ultra-high risk of psychosis: A systematic and quantitative review

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