Prediction of small for gestational age infants in healthy nulliparous women using clinical and ultrasound risk factors combined with early pregnancy biomarkers

Lesley M E McCowan; John M D Thompson; Rennae S. Taylor; Philip N. Baker; Robyn A. North; Lucilla Poston; Claire T. Roberts; Nigel A B Simpson; James J. Walker; Jenny Myers; Louise C. Kenny; D. Healy; A. Briley; N. Murphy; E. Snapes; Eliza Chan; Mik Black

doi:10.1371/journal.pone.0169311

Prediction of small for gestational age infants in healthy nulliparous women using clinical and ultrasound risk factors combined with early pregnancy biomarkers

Lesley M E McCowan, John M D Thompson, Rennae S. Taylor, Philip N. Baker, Robyn A. North, Lucilla Poston, Claire T. Roberts, Nigel A B Simpson, James J. Walker, Jenny Myers, Louise C. Kenny, D. Healy, A. Briley, N. Murphy, E. Snapes, Eliza Chan, Mik Black

Women & Children's Health

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

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Abstract

Objective: Most small for gestational age pregnancies are unrecognised before birth, resulting in substantial avoidable perinatal mortality and morbidity. Our objective was to develop multivariable prediction models for small for gestational age combining clinical risk factors and biomarkers at 15±1 weeks' with ultrasound parameters at 20±1 weeks' gestation. Methods: Data from 5606 participants in the Screening for Pregnancy Endpoints (SCOPE) cohort study were divided into Training (n = 3735) and Validation datasets (n = 1871). The primary outcomes were All-SGA (small for gestational age with birthweight

Original language	English
Article number	e0169311
Journal	PL o S One
Volume	12
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0169311
Publication status	Published - 9 Jan 2017

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Prediction of small for gestational age infants_MCCOWAN_Published9January2017_GOLD VoR (CC-BY)Final published version, 1.41 MBLicence: CC BY

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McCowan, L. M. E., Thompson, J. M. D., Taylor, R. S., Baker, P. N., North, R. A., Poston, L., Roberts, C. T., Simpson, N. A. B., Walker, J. J., Myers, J., Kenny, L. C., Healy, D., Briley, A., Murphy, N., Snapes, E., Chan, E., & Black, M. (2017). Prediction of small for gestational age infants in healthy nulliparous women using clinical and ultrasound risk factors combined with early pregnancy biomarkers. PL o S One , 12(1), Article e0169311. https://doi.org/10.1371/journal.pone.0169311

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title = "Prediction of small for gestational age infants in healthy nulliparous women using clinical and ultrasound risk factors combined with early pregnancy biomarkers",

abstract = "Objective: Most small for gestational age pregnancies are unrecognised before birth, resulting in substantial avoidable perinatal mortality and morbidity. Our objective was to develop multivariable prediction models for small for gestational age combining clinical risk factors and biomarkers at 15±1 weeks' with ultrasound parameters at 20±1 weeks' gestation. Methods: Data from 5606 participants in the Screening for Pregnancy Endpoints (SCOPE) cohort study were divided into Training (n = 3735) and Validation datasets (n = 1871). The primary outcomes were All-SGA (small for gestational age with birthweight ",

author = "McCowan, {Lesley M E} and Thompson, {John M D} and Taylor, {Rennae S.} and Baker, {Philip N.} and North, {Robyn A.} and Lucilla Poston and Roberts, {Claire T.} and Simpson, {Nigel A B} and Walker, {James J.} and Jenny Myers and Kenny, {Louise C.} and D. Healy and A. Briley and N. Murphy and E. Snapes and Eliza Chan and Mik Black",

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McCowan, LME, Thompson, JMD, Taylor, RS, Baker, PN, North, RA , Poston, L, Roberts, CT, Simpson, NAB, Walker, JJ, Myers, J, Kenny, LC, Healy, D, Briley, A, Murphy, N, Snapes, E, Chan, E & Black, M 2017, 'Prediction of small for gestational age infants in healthy nulliparous women using clinical and ultrasound risk factors combined with early pregnancy biomarkers', PL o S One , vol. 12, no. 1, e0169311. https://doi.org/10.1371/journal.pone.0169311

TY - JOUR

T1 - Prediction of small for gestational age infants in healthy nulliparous women using clinical and ultrasound risk factors combined with early pregnancy biomarkers

AU - McCowan, Lesley M E

AU - Thompson, John M D

AU - Taylor, Rennae S.

AU - Baker, Philip N.

AU - North, Robyn A.

AU - Poston, Lucilla

AU - Roberts, Claire T.

AU - Simpson, Nigel A B

AU - Walker, James J.

AU - Myers, Jenny

AU - Kenny, Louise C.

AU - Healy, D.

AU - Briley, A.

AU - Murphy, N.

AU - Snapes, E.

AU - Chan, Eliza

AU - Black, Mik

PY - 2017/1/9

Y1 - 2017/1/9

N2 - Objective: Most small for gestational age pregnancies are unrecognised before birth, resulting in substantial avoidable perinatal mortality and morbidity. Our objective was to develop multivariable prediction models for small for gestational age combining clinical risk factors and biomarkers at 15±1 weeks' with ultrasound parameters at 20±1 weeks' gestation. Methods: Data from 5606 participants in the Screening for Pregnancy Endpoints (SCOPE) cohort study were divided into Training (n = 3735) and Validation datasets (n = 1871). The primary outcomes were All-SGA (small for gestational age with birthweight

AB - Objective: Most small for gestational age pregnancies are unrecognised before birth, resulting in substantial avoidable perinatal mortality and morbidity. Our objective was to develop multivariable prediction models for small for gestational age combining clinical risk factors and biomarkers at 15±1 weeks' with ultrasound parameters at 20±1 weeks' gestation. Methods: Data from 5606 participants in the Screening for Pregnancy Endpoints (SCOPE) cohort study were divided into Training (n = 3735) and Validation datasets (n = 1871). The primary outcomes were All-SGA (small for gestational age with birthweight

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JO - PL o S One

JF - PL o S One

IS - 1

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ER -

Prediction of small for gestational age infants in healthy nulliparous women using clinical and ultrasound risk factors combined with early pregnancy biomarkers

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