Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review

Romina Fakhraei; Kathryn Denize; Alexandre Simon; Ayni Sharif; Julia Zhu-Pawlowsky; Alysha L.J. Dingwall-Harvey; Brian Hutton; Misty Pratt; Becky Skidmore; Nadera Ahmadzai; Nicola Heslehurst; Louise Hayes; Angela C. Flynn; Maria P. Velez; Graeme Smith; Andrea Lanes; Natalie Rybak; Mark Walker; Laura Gaudet

doi:10.3390/ijerph19042063

Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review

Romina Fakhraei, Kathryn Denize, Alexandre Simon, Ayni Sharif, Julia Zhu-Pawlowsky, Alysha L.J. Dingwall-Harvey, Brian Hutton, Misty Pratt, Becky Skidmore, Nadera Ahmadzai, Nicola Heslehurst, Louise Hayes, Angela C. Flynn, Maria P. Velez, Graeme Smith, Andrea Lanes, Natalie Rybak, Mark Walker, Laura Gaudet^*

^*Corresponding author for this work

Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Obesity is a well-recognized risk factor for pregnancy complications. Most studies to date are in large cohorts, with results presented in a way that assumes all women living with obesity are at equal risk. This study investigates which women living with obesity are at higher risk of specific pregnancy complications. A systematic search of MEDLINE and Embase identified 7894 prospective or retrospective cohort studies exploring predictors of adverse outcomes among pregnant women living with obesity. Following screening, 61 studies were deemed eligible. Studies were selected if the effects of exposure to any predictor amongst pregnant women living with obesity could be collected. Maternal characteristics assessed for association with adverse outcomes included maternal age, race/ethnicity, maternal height, mode of conception, complement activation factors, and history of various comorbidities/procedures. Gestational diabetes mellitus was the most studied outcome (n = 32), followed by preterm birth (n = 29), preeclampsia (n = 27), low birthweight infants (n = 20), small for gestational age newborns (n = 12), and stillbirth (n = 7). This review identified important characteristics that should be considered during the screening and follow-up sessions of pregnant women living with obesity, including pre-existing type 1 diabetes, maternal age <20 years or ≥35 years, non-White ethnicity, abdominal adiposity obesity, and history of bariatric surgery.

Original language	English
Article number	2063
Journal	International Journal of Environmental Research and Public Health
Volume	19
Issue number	4
DOIs	https://doi.org/10.3390/ijerph19042063
Publication status	Published - 1 Feb 2022

Keywords

Adverse outcomes
Obesity
Predictors
Pregnancy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/ijerph19042063

Cite this

Fakhraei, R., Denize, K., Simon, A., Sharif, A., Zhu-Pawlowsky, J., Dingwall-Harvey, A. L. J., Hutton, B., Pratt, M., Skidmore, B., Ahmadzai, N., Heslehurst, N., Hayes, L., Flynn, A. C., Velez, M. P., Smith, G., Lanes, A., Rybak, N., Walker, M., & Gaudet, L. (2022). Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review. International Journal of Environmental Research and Public Health, 19(4), Article 2063. https://doi.org/10.3390/ijerph19042063

@article{313a11fbb40f40f8bf6ff59f2c5db984,

title = "Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review",

abstract = "Obesity is a well-recognized risk factor for pregnancy complications. Most studies to date are in large cohorts, with results presented in a way that assumes all women living with obesity are at equal risk. This study investigates which women living with obesity are at higher risk of specific pregnancy complications. A systematic search of MEDLINE and Embase identified 7894 prospective or retrospective cohort studies exploring predictors of adverse outcomes among pregnant women living with obesity. Following screening, 61 studies were deemed eligible. Studies were selected if the effects of exposure to any predictor amongst pregnant women living with obesity could be collected. Maternal characteristics assessed for association with adverse outcomes included maternal age, race/ethnicity, maternal height, mode of conception, complement activation factors, and history of various comorbidities/procedures. Gestational diabetes mellitus was the most studied outcome (n = 32), followed by preterm birth (n = 29), preeclampsia (n = 27), low birthweight infants (n = 20), small for gestational age newborns (n = 12), and stillbirth (n = 7). This review identified important characteristics that should be considered during the screening and follow-up sessions of pregnant women living with obesity, including pre-existing type 1 diabetes, maternal age <20 years or ≥35 years, non-White ethnicity, abdominal adiposity obesity, and history of bariatric surgery.",

keywords = "Adverse outcomes, Obesity, Predictors, Pregnancy",

author = "Romina Fakhraei and Kathryn Denize and Alexandre Simon and Ayni Sharif and Julia Zhu-Pawlowsky and Dingwall-Harvey, {Alysha L.J.} and Brian Hutton and Misty Pratt and Becky Skidmore and Nadera Ahmadzai and Nicola Heslehurst and Louise Hayes and Flynn, {Angela C.} and Velez, {Maria P.} and Graeme Smith and Andrea Lanes and Natalie Rybak and Mark Walker and Laura Gaudet",

note = "Funding Information: Funding: This study was funded by the Canadian Institutes of Health Research (CIHR) agency (Grant #MFM-146444). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = feb,

day = "1",

doi = "10.3390/ijerph19042063",

language = "English",

volume = "19",

journal = "International Journal of Environmental Research and Public Health",

issn = "1661-7827",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "4",

}

Fakhraei, R, Denize, K, Simon, A, Sharif, A, Zhu-Pawlowsky, J, Dingwall-Harvey, ALJ, Hutton, B, Pratt, M, Skidmore, B, Ahmadzai, N, Heslehurst, N, Hayes, L, Flynn, AC, Velez, MP, Smith, G, Lanes, A, Rybak, N, Walker, M & Gaudet, L 2022, 'Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review', International Journal of Environmental Research and Public Health, vol. 19, no. 4, 2063. https://doi.org/10.3390/ijerph19042063

TY - JOUR

T1 - Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity

T2 - A Systematic Review

AU - Fakhraei, Romina

AU - Denize, Kathryn

AU - Simon, Alexandre

AU - Sharif, Ayni

AU - Zhu-Pawlowsky, Julia

AU - Dingwall-Harvey, Alysha L.J.

AU - Hutton, Brian

AU - Pratt, Misty

AU - Skidmore, Becky

AU - Ahmadzai, Nadera

AU - Heslehurst, Nicola

AU - Hayes, Louise

AU - Flynn, Angela C.

AU - Velez, Maria P.

AU - Smith, Graeme

AU - Lanes, Andrea

AU - Rybak, Natalie

AU - Walker, Mark

AU - Gaudet, Laura

N1 - Funding Information: Funding: This study was funded by the Canadian Institutes of Health Research (CIHR) agency (Grant #MFM-146444). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/2/1

Y1 - 2022/2/1

N2 - Obesity is a well-recognized risk factor for pregnancy complications. Most studies to date are in large cohorts, with results presented in a way that assumes all women living with obesity are at equal risk. This study investigates which women living with obesity are at higher risk of specific pregnancy complications. A systematic search of MEDLINE and Embase identified 7894 prospective or retrospective cohort studies exploring predictors of adverse outcomes among pregnant women living with obesity. Following screening, 61 studies were deemed eligible. Studies were selected if the effects of exposure to any predictor amongst pregnant women living with obesity could be collected. Maternal characteristics assessed for association with adverse outcomes included maternal age, race/ethnicity, maternal height, mode of conception, complement activation factors, and history of various comorbidities/procedures. Gestational diabetes mellitus was the most studied outcome (n = 32), followed by preterm birth (n = 29), preeclampsia (n = 27), low birthweight infants (n = 20), small for gestational age newborns (n = 12), and stillbirth (n = 7). This review identified important characteristics that should be considered during the screening and follow-up sessions of pregnant women living with obesity, including pre-existing type 1 diabetes, maternal age <20 years or ≥35 years, non-White ethnicity, abdominal adiposity obesity, and history of bariatric surgery.

AB - Obesity is a well-recognized risk factor for pregnancy complications. Most studies to date are in large cohorts, with results presented in a way that assumes all women living with obesity are at equal risk. This study investigates which women living with obesity are at higher risk of specific pregnancy complications. A systematic search of MEDLINE and Embase identified 7894 prospective or retrospective cohort studies exploring predictors of adverse outcomes among pregnant women living with obesity. Following screening, 61 studies were deemed eligible. Studies were selected if the effects of exposure to any predictor amongst pregnant women living with obesity could be collected. Maternal characteristics assessed for association with adverse outcomes included maternal age, race/ethnicity, maternal height, mode of conception, complement activation factors, and history of various comorbidities/procedures. Gestational diabetes mellitus was the most studied outcome (n = 32), followed by preterm birth (n = 29), preeclampsia (n = 27), low birthweight infants (n = 20), small for gestational age newborns (n = 12), and stillbirth (n = 7). This review identified important characteristics that should be considered during the screening and follow-up sessions of pregnant women living with obesity, including pre-existing type 1 diabetes, maternal age <20 years or ≥35 years, non-White ethnicity, abdominal adiposity obesity, and history of bariatric surgery.

KW - Adverse outcomes

KW - Obesity

KW - Predictors

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85124344868&partnerID=8YFLogxK

U2 - 10.3390/ijerph19042063

DO - 10.3390/ijerph19042063

M3 - Article

AN - SCOPUS:85124344868

SN - 1661-7827

VL - 19

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

IS - 4

M1 - 2063

ER -

Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this