Preferential induction of apoptosis of leukaemic cells by farnesol

TY - JOUR

T1 - Preferential induction of apoptosis of leukaemic cells by farnesol

AU - Rioja, A

AU - Pizzey, A R

AU - Marson, C M

AU - Thomas, N S B

PY - 2000/2/11

Y1 - 2000/2/11

N2 - Farnesol preferentially inhibits proliferation and induces apoptosis of tumour-derived but not non-transformed cell lines. We investigated whether farnesol induces apoptosis of blasts from patients with acute myeloid leukaemia (AML) and leukaemic cell lines, as compared with normal, human primary haemopoietic cells, We show that 30 mu M farnesol causes apoptosis of leukaemic cell lines of T- and B-lymphocyte, myeloid or erythroid lineages and primary blasts obtained from patients with AML. However, the same concentration did not kill primary monocytes, or quiescent or proliferating T-lymphocytes. We conclude that farnesol selectively kills AML blasts and leukaemic cell lines in preference to primary haemopoietic cells. (C) 2000 Federation of European Biochemical Societies.

AB - Farnesol preferentially inhibits proliferation and induces apoptosis of tumour-derived but not non-transformed cell lines. We investigated whether farnesol induces apoptosis of blasts from patients with acute myeloid leukaemia (AML) and leukaemic cell lines, as compared with normal, human primary haemopoietic cells, We show that 30 mu M farnesol causes apoptosis of leukaemic cell lines of T- and B-lymphocyte, myeloid or erythroid lineages and primary blasts obtained from patients with AML. However, the same concentration did not kill primary monocytes, or quiescent or proliferating T-lymphocytes. We conclude that farnesol selectively kills AML blasts and leukaemic cell lines in preference to primary haemopoietic cells. (C) 2000 Federation of European Biochemical Societies.

UR - https://www.scopus.com/pages/publications/0033968452

U2 - 10.1016/S0014-5793(00)01168-6

DO - 10.1016/S0014-5793(00)01168-6

M3 - Article

VL - 467

SP - 291

EP - 295

JO - FEBS Letters

JF - FEBS Letters

IS - 2-3

ER -