TY - CHAP
T1 - Prefrontal cortical folding of the preterm brain
T2 - 3rd International Workshop on Spatio-temporal Image Analysis for Longitudinal and Time-Series Image Data, STIA 2014 in conjunction with the International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2014
AU - Orasanu, Eliza
AU - Melbourne, Andrew
AU - Lombaert, Herve
AU - Cardoso, Manuel Jorge
AU - Johnsen, Stian Flage
AU - Kendall, Giles S.
AU - Robertson, Nicola J.
AU - Marlow, Neil
AU - Ourselin, Sebastien
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Very preterm birth (less than 32 weeks completed gestation) coincides with a rapid period of brain growth and development. Investigating the changes of certain brain regions may allow the development of biomarkers for predicting neurological outcome. The prefrontal cortex, associated with the executive function, undergoes major changes during the last 10 weeks of pregnancy, and therefore its development may be altered by very-preterm birth. In this paper we use surface-based spectral matching techniques to analyse how the prefrontal cortex develops between 30 weeks and 40 weeks equivalent gestational age in 5 infants born preterm. Using this method, we can accurately map the regions where the secondary and tertiary sulci and gyri of the prefrontal cortex will form. Additionally, measurements of cortical curvature can be used to estimate the local bending energy required to generate the observed pattern of cortical folding. Longitudinal measurement of the cortical folding change can provide information about the mechanical properties of the underlying tissue and may be useful in discriminating mechanical changes during growth in this vulnerable period of development.
AB - Very preterm birth (less than 32 weeks completed gestation) coincides with a rapid period of brain growth and development. Investigating the changes of certain brain regions may allow the development of biomarkers for predicting neurological outcome. The prefrontal cortex, associated with the executive function, undergoes major changes during the last 10 weeks of pregnancy, and therefore its development may be altered by very-preterm birth. In this paper we use surface-based spectral matching techniques to analyse how the prefrontal cortex develops between 30 weeks and 40 weeks equivalent gestational age in 5 infants born preterm. Using this method, we can accurately map the regions where the secondary and tertiary sulci and gyri of the prefrontal cortex will form. Additionally, measurements of cortical curvature can be used to estimate the local bending energy required to generate the observed pattern of cortical folding. Longitudinal measurement of the cortical folding change can provide information about the mechanical properties of the underlying tissue and may be useful in discriminating mechanical changes during growth in this vulnerable period of development.
UR - http://www.scopus.com/inward/record.url?scp=84927928338&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-14905-9_1
DO - 10.1007/978-3-319-14905-9_1
M3 - Conference paper
AN - SCOPUS:84927928338
VL - 8682
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 3
EP - 12
BT - Spatio-temporal Image Analysis for Longitudinal and Time-Series Image Data - 3rd International Workshop, STIA 2014 Held in Conjunction with MICCAI 2014, Revised Selected Papers
PB - Springer Verlag
Y2 - 18 September 2014 through 18 September 2014
ER -