Pregnancy and bile acid disorders

Vanessa Pataia; Peter H Dixon; Catherine Williamson

doi:10.1152/ajpgi.00028.2017

Pregnancy and bile acid disorders

Vanessa Pataia, Peter H Dixon, Catherine Williamson

Women & Children's Health

King's College London

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

During pregnancy, extensive adaptations in maternal metabolic and immunological physiology occur. Consequently, pre-existing disease may be exacerbated or attenuated and new disease susceptibility may be unmasked. Cholestatic diseases, characterized by a supraphysiological raise in bile acid levels, require careful monitoring during pregnancy. This review describes the latest advances in the knowledge of intrahepatic cholestasis of pregnancy (ICP), the commonest bile acid disorder specific to pregnancy, with a focus on the disease etiology and potential mechanisms of ICP-associated adverse pregnancy outcomes, including fetal demise. The course of pre-existing cholestatic conditions in pregnancy is considered, including primary sclerosing cholangitis, primary biliary cholangitis, biliary atresia and Alagille syndrome. The currently accepted treatments for cholestasis in pregnancy and promising new therapeutics for the condition are described.

Original language	English
Pages (from-to)	G1-G6
Journal	AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Volume	313
Issue number	1
DOIs	https://doi.org/10.1152/ajpgi.00028.2017
Publication status	Published - 27 Apr 2017

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1152/ajpgi.00028.2017

Cite this

@article{2c8c522e2ec74139b2928d3d03b7f83b,

title = "Pregnancy and bile acid disorders",

abstract = "During pregnancy, extensive adaptations in maternal metabolic and immunological physiology occur. Consequently, pre-existing disease may be exacerbated or attenuated and new disease susceptibility may be unmasked. Cholestatic diseases, characterized by a supraphysiological raise in bile acid levels, require careful monitoring during pregnancy. This review describes the latest advances in the knowledge of intrahepatic cholestasis of pregnancy (ICP), the commonest bile acid disorder specific to pregnancy, with a focus on the disease etiology and potential mechanisms of ICP-associated adverse pregnancy outcomes, including fetal demise. The course of pre-existing cholestatic conditions in pregnancy is considered, including primary sclerosing cholangitis, primary biliary cholangitis, biliary atresia and Alagille syndrome. The currently accepted treatments for cholestasis in pregnancy and promising new therapeutics for the condition are described.",

keywords = "Journal Article",

author = "Vanessa Pataia and Dixon, {Peter H} and Catherine Williamson",

note = "Copyright {\textcopyright} 2017, American Journal of Physiology-Gastrointestinal and Liver Physiology.",

year = "2017",

month = apr,

day = "27",

doi = "10.1152/ajpgi.00028.2017",

language = "English",

volume = "313",

pages = "G1--G6",

journal = "AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY",

issn = "0193-1857",

publisher = "American Physiological Society",

number = "1",

}

TY - JOUR

T1 - Pregnancy and bile acid disorders

AU - Pataia, Vanessa

AU - Dixon, Peter H

AU - Williamson, Catherine

PY - 2017/4/27

Y1 - 2017/4/27

N2 - During pregnancy, extensive adaptations in maternal metabolic and immunological physiology occur. Consequently, pre-existing disease may be exacerbated or attenuated and new disease susceptibility may be unmasked. Cholestatic diseases, characterized by a supraphysiological raise in bile acid levels, require careful monitoring during pregnancy. This review describes the latest advances in the knowledge of intrahepatic cholestasis of pregnancy (ICP), the commonest bile acid disorder specific to pregnancy, with a focus on the disease etiology and potential mechanisms of ICP-associated adverse pregnancy outcomes, including fetal demise. The course of pre-existing cholestatic conditions in pregnancy is considered, including primary sclerosing cholangitis, primary biliary cholangitis, biliary atresia and Alagille syndrome. The currently accepted treatments for cholestasis in pregnancy and promising new therapeutics for the condition are described.

AB - During pregnancy, extensive adaptations in maternal metabolic and immunological physiology occur. Consequently, pre-existing disease may be exacerbated or attenuated and new disease susceptibility may be unmasked. Cholestatic diseases, characterized by a supraphysiological raise in bile acid levels, require careful monitoring during pregnancy. This review describes the latest advances in the knowledge of intrahepatic cholestasis of pregnancy (ICP), the commonest bile acid disorder specific to pregnancy, with a focus on the disease etiology and potential mechanisms of ICP-associated adverse pregnancy outcomes, including fetal demise. The course of pre-existing cholestatic conditions in pregnancy is considered, including primary sclerosing cholangitis, primary biliary cholangitis, biliary atresia and Alagille syndrome. The currently accepted treatments for cholestasis in pregnancy and promising new therapeutics for the condition are described.

KW - Journal Article

U2 - 10.1152/ajpgi.00028.2017

DO - 10.1152/ajpgi.00028.2017

M3 - Article

C2 - 28450276

SN - 0193-1857

VL - 313

SP - G1-G6

JO - AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

JF - AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

IS - 1

ER -

Pregnancy and bile acid disorders

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this