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Pregnancy Outcome in Women with Chronic Kidney Disease: A Prospective Cohort Study

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)623 - 630
Number of pages8
JournalReproductive Sciences
Issue number7
PublishedJul 2011

King's Authors


Objective: To evaluate pregnancy outcome in women with chronic kidney disease (CKD) or proteinuria in early pregnancy with concomitant risk for preeclampsia (PE). Methods: Thirty-six women with CKD (Cr > 100 mu mol/L at booking or Cr > 125 mu mol/L prepregnancy or proteinuria >= 500 mg/24 hours at booking) and 30 women with proteinuria (>= 2+) and known clinical risk for PE were enrolled at 14(+0) to 21(+6) weeks. Pregnancy outcomes were assessed. Results: Women with mild CKD (prepregnancy Cr <125 mu mol/Cr > 100 mu mol at booking; n = 22) had high rates of preeclampsia (40%), preterm delivery ( 125 mu mol; n = 14) had poor perinatal outcomes: preterm delivery (86%) and perinatal death (14%). Women with proteinuria (>= 2+) and concomitant risk of PE also had high rates of pre-eclampsia (60%), preterm delivery (40%), and SGA infants (27%). Conclusions: Pregnancy complications for women with CKD remain high. Women with risk factors for PE with proteinuria (>= 2+) at booking are also high-risk.

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