Abstract
With our interests in frailty and prehabilitation, we read the Carli et al article1 with great interest because they are leaders in the field who we look to for insight and evidence. While the authors are to be commended for this work, there are several key features that limit their conclusion.
The authors state this is a superiority trial implying this study was confirmatory and adequately powered to detect a clinical difference. This is in contrast to the objectives within the protocol (Supplement 2) and study registration because it states the study was to explore differences. Furthermore, the clinical effect size used within the power calculation may be considered overly optimistic and unrealistic, resulting in this study being more consistent with an early-phase underpowered study, unlikely to detect a difference.
The authors state this is a superiority trial implying this study was confirmatory and adequately powered to detect a clinical difference. This is in contrast to the objectives within the protocol (Supplement 2) and study registration because it states the study was to explore differences. Furthermore, the clinical effect size used within the power calculation may be considered overly optimistic and unrealistic, resulting in this study being more consistent with an early-phase underpowered study, unlikely to detect a difference.
| Original language | English |
|---|---|
| Number of pages | 1 |
| Journal | Jama surgery |
| Volume | 155 |
| Issue number | 9 |
| DOIs |
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| Publication status | Published - Sept 2020 |