Preparation and application of hydrophilic monolithic columns

Zhengjin Jiang, Norman William Smith, Zhenghua Liu

Research output: Contribution to journalConference paper

89 Citations (Scopus)


Hydrophilic interaction chromatography (HILIC) has experienced increasing attention in recent years. Much research has been carried out in the area of HILIC separation mechanisms, column techniques and applications. Because of their good permeability, low resistance to mass transfer and easy preparation within capillaries, hydrophilic monolithic columns represent a trend among novel HILIC column techniques. This review attempts to present an overview of the preparation and applications of HILIC monolithic columns carried out in the past decade. The separation mechanism of various hydrophilic monolithic stationary phases is also reviewed. (C) 2011 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)2350 - 2361
Number of pages12
JournalJournal of Chromatography A
Issue number17
Publication statusPublished - 29 Apr 2011
Event4th Summer School of Monolith Technology for Biochromatography, Bioconversion and Phase State Synthesis - Portoroz, Slovenia
Duration: 30 May 20102 Jun 2010


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