Preparation and stability of a radioiodinated pentamidine isethionate analog

TY - JOUR

T1 - Preparation and stability of a radioiodinated pentamidine isethionate analog

AU - Blower, P J

AU - Smith, C M

AU - Smith, R J

AU - Moores, G E

AU - O'Doherty, M J

PY - 1992/10

Y1 - 1992/10

N2 - Iodopentamidine isethionate was heated for 70 min with [I-123]- or [I-125]-sodium iodide and ammonium sulphate in the absence of solvent at 140 degrees C. The product, [I-123]- or [I-125]-iodopentamidine isethionate, was purified by ion exchange chromatography. It was stable at room temperature in aqueous solution over several days, in human blood in vitro for at least 24 h (showing no binding to either cells or proteins), in urine over at least 15 h, and during nebulization in both ultrasonic and jet nebulizers.

AB - Iodopentamidine isethionate was heated for 70 min with [I-123]- or [I-125]-sodium iodide and ammonium sulphate in the absence of solvent at 140 degrees C. The product, [I-123]- or [I-125]-iodopentamidine isethionate, was purified by ion exchange chromatography. It was stable at room temperature in aqueous solution over several days, in human blood in vitro for at least 24 h (showing no binding to either cells or proteins), in urine over at least 15 h, and during nebulization in both ultrasonic and jet nebulizers.

M3 - Article

C2 - 1330978

SN - 0883-2889

VL - 43

SP - 1189

EP - 1195

JO - International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes

JF - International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes

IS - 10

ER -