TY - JOUR
T1 - Preparation and use of I-131 MAGIC gel as a dosimeter for targeted radionuclide therapy
AU - Courbon, F.
AU - Love, P.
AU - Chittenden, S.
AU - Flux, G.
AU - Ravel, P.
AU - Cook, G.
N1 - M1 - 5
Courbon, Frederic Love, Peter Chittenden, Sarah Flux, Glen Ravel, Patrice Cook, Gary
PY - 2006
Y1 - 2006
N2 - Clinical interest in targeted radiotherapy is increasing, but accurate dosimetry studies are difficult to achieve. The aim of this study was to investigate the preparation and use of a "normoxic" polymer gel (with a tissue-equivalent density), known as MAGIC gel, and magnetic resonance imaging (MRI) for nonsealed source dosimetry. MAGIC gel samples were mixed with deionized water (MAGIC(95)) or a solution Of I-131 (I-131-MAGIC(95)). By measuring the radioinduced variations of R-2 values (relaxivity) of irradiated gels, we analyzed the response of MAGIC95 and MAGIC samples to external photon beam or I-131 irradiation (I-131-MAGIC(95)). MRI showed that a homogeneous dose distribution from I-131 can be achieved if the MAGIC gel, at a temperature of approximately 35 degrees C, is mixed in I-131 solution and the resulting mixture shaken gently for 30 minutes. It is important that the vials are completely filled, as residual air reduces polymerization and causes spontaneous polymerization stripes. Responses Of MAGIC95 or MAGIC gels to external photon beam irradiation are similar. The variations of R-2 values for I-131-MAGIC(95) gel depend on the absorbed dose and not on the duration of the irradiation being reproducible from one batch of gel to another. MAGIC gel responses to I-131 or external beam irradiation (EBI) are different. Our preliminary results suggest that radiolabeled "normoxic" polymer can be easily and safely produced. Radiolabeled MAGIC gel may, therefore, be suitable for the creation of phantoms dedicated to nonsealed source dosimetry.
AB - Clinical interest in targeted radiotherapy is increasing, but accurate dosimetry studies are difficult to achieve. The aim of this study was to investigate the preparation and use of a "normoxic" polymer gel (with a tissue-equivalent density), known as MAGIC gel, and magnetic resonance imaging (MRI) for nonsealed source dosimetry. MAGIC gel samples were mixed with deionized water (MAGIC(95)) or a solution Of I-131 (I-131-MAGIC(95)). By measuring the radioinduced variations of R-2 values (relaxivity) of irradiated gels, we analyzed the response of MAGIC95 and MAGIC samples to external photon beam or I-131 irradiation (I-131-MAGIC(95)). MRI showed that a homogeneous dose distribution from I-131 can be achieved if the MAGIC gel, at a temperature of approximately 35 degrees C, is mixed in I-131 solution and the resulting mixture shaken gently for 30 minutes. It is important that the vials are completely filled, as residual air reduces polymerization and causes spontaneous polymerization stripes. Responses Of MAGIC95 or MAGIC gels to external photon beam irradiation are similar. The variations of R-2 values for I-131-MAGIC(95) gel depend on the absorbed dose and not on the duration of the irradiation being reproducible from one batch of gel to another. MAGIC gel responses to I-131 or external beam irradiation (EBI) are different. Our preliminary results suggest that radiolabeled "normoxic" polymer can be easily and safely produced. Radiolabeled MAGIC gel may, therefore, be suitable for the creation of phantoms dedicated to nonsealed source dosimetry.
U2 - 10.1089/cbr.2006.21.427
DO - 10.1089/cbr.2006.21.427
M3 - Article
SN - 1084-9785
VL - 21
SP - 427
EP - 436
JO - CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
JF - CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
IS - 5
ER -
