Abstract
Background: Pressure recording analytical method (PRAM) is a novel, arterial pulse contour-based method for measuring cardiac output (CO). Validation studies of PRAM in children are few, and have not assessed both absolute accuracy and ability to track changes in CO across a broad case mix. We aimed to compare CO as measured by PRAM with that using a transpulmonary dilution method in a cohort of critically ill children.
Methods: Forty-eight, mechanically ventilated children with a median (inter-quartile) weight of 10.7 (5.515) kg with arterial and central venous catheters in situ were studied. CO was measured simultaneously using PRAM and the comparator method, transpulmonary ultrasound dilution (UD). Measurements were repeated before and after therapeutic interventions that were intended to augment CO (e.g. fluid bolus).
Results: In total, 210 paired measurements were compared. The mean (sd) CO was 1.9 (1.2) litre min(1) with UD when compared with 1.92 (0.5) litre min(1) using PRAM. The mean bias was 0.02 litre min(1) with wide limits of agreement: 2.21 litre min(1), giving a percentage error of 116. The concordance between PRAM and UD for measuring changes in CO was also poor, with only 37 of measurements falling within the pre-defined polar plot limits of 30.
Conclusions: There is an unacceptably poor agreement between UD and PRAM. We do not recommend the use of PRAM for measuring CO in critically ill children with the current algorithm.
| Original language | English |
|---|---|
| Pages (from-to) | 425-431 |
| Number of pages | 7 |
| Journal | British Journal of Anaesthesia |
| Volume | 110 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2013 |
Keywords
- cardiac output
- monitoring
- pressure recording analytical method
- ultrasound dilution
- ULTRASOUND DILUTION
- ARTERIAL-PRESSURE
- SURGERY
- INFANTS
- THERMODILUTION
- PERFORMANCE
- PRECISION
- AGREEMENT
- MONITORS
- DOPPLER