Preterm birth: Inflammation, fetal injury and treatment strategies

Ashley K. Boyle; Sara F. Rinaldi; Jane E. Norman; Sarah J. Stock

doi:10.1016/j.jri.2016.11.008

Preterm birth: Inflammation, fetal injury and treatment strategies

Ashley K. Boyle^*, Sara F. Rinaldi, Jane E. Norman, Sarah J. Stock

^*Corresponding author for this work

Women & Children's Health

University of Edinburgh

Research output: Contribution to journal › Review article › peer-review

133 Citations (Scopus)

Abstract

Preterm birth (PTB) is the leading cause of childhood mortality in children under 5 and accounts for approximately 11% of births worldwide. Premature babies are at risk of a number of health complications, notably cerebral palsy, but also respiratory and gastrointestinal disorders. Preterm deliveries can be medically indicated/elective procedures or they can occur spontaneously. Spontaneous PTB is commonly associated with intrauterine infection/inflammation. The presence of inflammatory mediators in utero has been associated with fetal injury, particularly affecting the fetal lungs and brain. This review will outline (i) the role of inflammation in term and PTB, (ii) the effect infection/inflammation has on fetal development and (iii) recent strategies to target PTB. Further research is urgently required to develop effective methods for the prevention and treatment of PTB and above all, to reduce fetal injury.

Original language	English
Pages (from-to)	62-66
Number of pages	5
Journal	Journal of Reproductive Immunology
Volume	119
DOIs	https://doi.org/10.1016/j.jri.2016.11.008
Publication status	Published - 1 Feb 2017

Keywords

Fetal injury
Inflammation
Preterm birth

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10.1016/j.jri.2016.11.008

Cite this

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title = "Preterm birth: Inflammation, fetal injury and treatment strategies",

abstract = "Preterm birth (PTB) is the leading cause of childhood mortality in children under 5 and accounts for approximately 11% of births worldwide. Premature babies are at risk of a number of health complications, notably cerebral palsy, but also respiratory and gastrointestinal disorders. Preterm deliveries can be medically indicated/elective procedures or they can occur spontaneously. Spontaneous PTB is commonly associated with intrauterine infection/inflammation. The presence of inflammatory mediators in utero has been associated with fetal injury, particularly affecting the fetal lungs and brain. This review will outline (i) the role of inflammation in term and PTB, (ii) the effect infection/inflammation has on fetal development and (iii) recent strategies to target PTB. Further research is urgently required to develop effective methods for the prevention and treatment of PTB and above all, to reduce fetal injury.",

keywords = "Fetal injury, Inflammation, Preterm birth",

author = "Boyle, {Ashley K.} and Rinaldi, {Sara F.} and Norman, {Jane E.} and Stock, {Sarah J.}",

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doi = "10.1016/j.jri.2016.11.008",

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TY - JOUR

T1 - Preterm birth

T2 - Inflammation, fetal injury and treatment strategies

AU - Boyle, Ashley K.

AU - Rinaldi, Sara F.

AU - Norman, Jane E.

AU - Stock, Sarah J.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Preterm birth (PTB) is the leading cause of childhood mortality in children under 5 and accounts for approximately 11% of births worldwide. Premature babies are at risk of a number of health complications, notably cerebral palsy, but also respiratory and gastrointestinal disorders. Preterm deliveries can be medically indicated/elective procedures or they can occur spontaneously. Spontaneous PTB is commonly associated with intrauterine infection/inflammation. The presence of inflammatory mediators in utero has been associated with fetal injury, particularly affecting the fetal lungs and brain. This review will outline (i) the role of inflammation in term and PTB, (ii) the effect infection/inflammation has on fetal development and (iii) recent strategies to target PTB. Further research is urgently required to develop effective methods for the prevention and treatment of PTB and above all, to reduce fetal injury.

AB - Preterm birth (PTB) is the leading cause of childhood mortality in children under 5 and accounts for approximately 11% of births worldwide. Premature babies are at risk of a number of health complications, notably cerebral palsy, but also respiratory and gastrointestinal disorders. Preterm deliveries can be medically indicated/elective procedures or they can occur spontaneously. Spontaneous PTB is commonly associated with intrauterine infection/inflammation. The presence of inflammatory mediators in utero has been associated with fetal injury, particularly affecting the fetal lungs and brain. This review will outline (i) the role of inflammation in term and PTB, (ii) the effect infection/inflammation has on fetal development and (iii) recent strategies to target PTB. Further research is urgently required to develop effective methods for the prevention and treatment of PTB and above all, to reduce fetal injury.

KW - Fetal injury

KW - Inflammation

KW - Preterm birth

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U2 - 10.1016/j.jri.2016.11.008

DO - 10.1016/j.jri.2016.11.008

M3 - Review article

C2 - 28122664

AN - SCOPUS:85028239837

SN - 0165-0378

VL - 119

SP - 62

EP - 66

JO - Journal of Reproductive Immunology

JF - Journal of Reproductive Immunology

ER -

Preterm birth: Inflammation, fetal injury and treatment strategies

Abstract

Keywords

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