Prevalence and Severity of Neuropsychiatric Symptoms in Early- Versus Late-Onset Alzheimer's Disease

Sarah Baillon; Amy Gasper; Frances Wilson-Morkeh; Megan Pritchard; Amala Jesu; Latha Velayudhan

doi:10.1177/1533317519841191

Prevalence and Severity of Neuropsychiatric Symptoms in Early- Versus Late-Onset Alzheimer's Disease

Sarah Baillon, Amy Gasper, Frances Wilson-Morkeh, Megan Pritchard, Amala Jesu, Latha Velayudhan

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

279 Downloads (Pure)

Abstract

BACKGROUND:: The study aimed to compare neuropsychiatric symptoms (NPS) in people with early-onset Alzheimer's disease (EOAD) and late-onset AD (LOAD).

METHODS:: Fifty-six participants with LOAD and 24 participants with EOAD having mild dementia were assessed for NPS for their frequency, severity, and caregiver distress as measured by Neuropsychiatry Inventory (NPI) along with assessments of cognition and functional dependence.

RESULTS:: Participants with EOAD and LOAD were not significantly different for total NPI score ( P = .057). Early-onset Alzheimer disease had greater prevalence of all the NPS except apathy. Participants with EOAD were significantly worse on anxiety ( P = .03), irritability ( P = .01), and sleep ( P < .01) subscales and their carers significantly more distressed by their irritability ( P = .002) and sleeping patterns ( P = .005). Regression analysis showed that higher NPI score was associated with longer duration of illness in EOAD and higher functional dependence in LOAD.

CONCLUSIONS:: The NPS severity was similar between EOAD and LOAD although EOAD had higher symptom prevalence and carer distress.

Original language	English
Pages (from-to)	433-438
Number of pages	6
Journal	American Journal of Alzheimer's Disease & Other Dementias
Volume	34
Issue number	7-8
Early online date	1 Apr 2019
DOIs	https://doi.org/10.1177/1533317519841191
Publication status	Published - 1 Nov 2019

Keywords

Alzheimer’s disease
Neuropsychiatry Inventory
caregiver stress
early-onset Alzheimer’s disease
neuropsychiatric symptoms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/1533317519841191

Prevalence and Severity of Neuropsychiatric_BAILLON_Accepted2March2019_GREEN AAMAccepted author manuscript, 253 KB

Cite this

@article{daebc2224be64ce087b628b5c6947f1d,

title = "Prevalence and Severity of Neuropsychiatric Symptoms in Early- Versus Late-Onset Alzheimer's Disease",

abstract = "BACKGROUND:: The study aimed to compare neuropsychiatric symptoms (NPS) in people with early-onset Alzheimer's disease (EOAD) and late-onset AD (LOAD).METHODS:: Fifty-six participants with LOAD and 24 participants with EOAD having mild dementia were assessed for NPS for their frequency, severity, and caregiver distress as measured by Neuropsychiatry Inventory (NPI) along with assessments of cognition and functional dependence.RESULTS:: Participants with EOAD and LOAD were not significantly different for total NPI score ( P = .057). Early-onset Alzheimer disease had greater prevalence of all the NPS except apathy. Participants with EOAD were significantly worse on anxiety ( P = .03), irritability ( P = .01), and sleep ( P < .01) subscales and their carers significantly more distressed by their irritability ( P = .002) and sleeping patterns ( P = .005). Regression analysis showed that higher NPI score was associated with longer duration of illness in EOAD and higher functional dependence in LOAD.CONCLUSIONS:: The NPS severity was similar between EOAD and LOAD although EOAD had higher symptom prevalence and carer distress.",

keywords = "Alzheimer{\textquoteright}s disease, Neuropsychiatry Inventory, caregiver stress, early-onset Alzheimer{\textquoteright}s disease, neuropsychiatric symptoms",

author = "Sarah Baillon and Amy Gasper and Frances Wilson-Morkeh and Megan Pritchard and Amala Jesu and Latha Velayudhan",

year = "2019",

month = nov,

day = "1",

doi = "10.1177/1533317519841191",

language = "English",

volume = "34",

pages = "433--438",

journal = "American Journal of Alzheimer's Disease & Other Dementias",

number = "7-8",

}

TY - JOUR

T1 - Prevalence and Severity of Neuropsychiatric Symptoms in Early- Versus Late-Onset Alzheimer's Disease

AU - Baillon, Sarah

AU - Gasper, Amy

AU - Wilson-Morkeh, Frances

AU - Pritchard, Megan

AU - Jesu, Amala

AU - Velayudhan, Latha

PY - 2019/11/1

Y1 - 2019/11/1

N2 - BACKGROUND:: The study aimed to compare neuropsychiatric symptoms (NPS) in people with early-onset Alzheimer's disease (EOAD) and late-onset AD (LOAD).METHODS:: Fifty-six participants with LOAD and 24 participants with EOAD having mild dementia were assessed for NPS for their frequency, severity, and caregiver distress as measured by Neuropsychiatry Inventory (NPI) along with assessments of cognition and functional dependence.RESULTS:: Participants with EOAD and LOAD were not significantly different for total NPI score ( P = .057). Early-onset Alzheimer disease had greater prevalence of all the NPS except apathy. Participants with EOAD were significantly worse on anxiety ( P = .03), irritability ( P = .01), and sleep ( P < .01) subscales and their carers significantly more distressed by their irritability ( P = .002) and sleeping patterns ( P = .005). Regression analysis showed that higher NPI score was associated with longer duration of illness in EOAD and higher functional dependence in LOAD.CONCLUSIONS:: The NPS severity was similar between EOAD and LOAD although EOAD had higher symptom prevalence and carer distress.

AB - BACKGROUND:: The study aimed to compare neuropsychiatric symptoms (NPS) in people with early-onset Alzheimer's disease (EOAD) and late-onset AD (LOAD).METHODS:: Fifty-six participants with LOAD and 24 participants with EOAD having mild dementia were assessed for NPS for their frequency, severity, and caregiver distress as measured by Neuropsychiatry Inventory (NPI) along with assessments of cognition and functional dependence.RESULTS:: Participants with EOAD and LOAD were not significantly different for total NPI score ( P = .057). Early-onset Alzheimer disease had greater prevalence of all the NPS except apathy. Participants with EOAD were significantly worse on anxiety ( P = .03), irritability ( P = .01), and sleep ( P < .01) subscales and their carers significantly more distressed by their irritability ( P = .002) and sleeping patterns ( P = .005). Regression analysis showed that higher NPI score was associated with longer duration of illness in EOAD and higher functional dependence in LOAD.CONCLUSIONS:: The NPS severity was similar between EOAD and LOAD although EOAD had higher symptom prevalence and carer distress.

KW - Alzheimer’s disease

KW - Neuropsychiatry Inventory

KW - caregiver stress

KW - early-onset Alzheimer’s disease

KW - neuropsychiatric symptoms

UR - http://www.scopus.com/inward/record.url?scp=85063967380&partnerID=8YFLogxK

U2 - 10.1177/1533317519841191

DO - 10.1177/1533317519841191

M3 - Article

C2 - 30935215

VL - 34

SP - 433

EP - 438

JO - American Journal of Alzheimer's Disease & Other Dementias

JF - American Journal of Alzheimer's Disease & Other Dementias

IS - 7-8

ER -

Prevalence and Severity of Neuropsychiatric Symptoms in Early- Versus Late-Onset Alzheimer's Disease

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this