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Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK

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Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK. / Jolliffe, David A.; James, Wai Yee; Hooper, Richard L.; Barnes, Neil C.; Greiller, Claire L.; Islam, Kamrul; Bhowmik, Angshu; Timms, Peter M.; Rajakulasingam, Raj K; Choudhury, Aklak B.; Simcock, David E.; Hyppönen, Elina; Walton, Robert T.; Corrigan, Christopher J.; Griffiths, Christopher J.; Martineau, Adrian R.

In: Journal of Steroid Biochemistry and Molecular Biology, 02.2017.

Research output: Contribution to journalArticle

Harvard

Jolliffe, DA, James, WY, Hooper, RL, Barnes, NC, Greiller, CL, Islam, K, Bhowmik, A, Timms, PM, Rajakulasingam, RK, Choudhury, AB, Simcock, DE, Hyppönen, E, Walton, RT, Corrigan, CJ, Griffiths, CJ & Martineau, AR 2017, 'Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK', Journal of Steroid Biochemistry and Molecular Biology. https://doi.org/10.1016/j.jsbmb.2017.01.019

APA

Jolliffe, D. A., James, W. Y., Hooper, R. L., Barnes, N. C., Greiller, C. L., Islam, K., Bhowmik, A., Timms, P. M., Rajakulasingam, R. K., Choudhury, A. B., Simcock, D. E., Hyppönen, E., Walton, R. T., Corrigan, C. J., Griffiths, C. J., & Martineau, A. R. (2017). Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK. Journal of Steroid Biochemistry and Molecular Biology. https://doi.org/10.1016/j.jsbmb.2017.01.019

Vancouver

Jolliffe DA, James WY, Hooper RL, Barnes NC, Greiller CL, Islam K et al. Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK. Journal of Steroid Biochemistry and Molecular Biology. 2017 Feb. https://doi.org/10.1016/j.jsbmb.2017.01.019

Author

Jolliffe, David A. ; James, Wai Yee ; Hooper, Richard L. ; Barnes, Neil C. ; Greiller, Claire L. ; Islam, Kamrul ; Bhowmik, Angshu ; Timms, Peter M. ; Rajakulasingam, Raj K ; Choudhury, Aklak B. ; Simcock, David E. ; Hyppönen, Elina ; Walton, Robert T. ; Corrigan, Christopher J. ; Griffiths, Christopher J. ; Martineau, Adrian R. / Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK. In: Journal of Steroid Biochemistry and Molecular Biology. 2017.

Bibtex Download

@article{80766cdb7cc94ecab927d58577dfc765,
title = "Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK",
abstract = "Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD), yet a comprehensive analysis of environmental and genetic determinants of serum 25-hydroxyvitamin D (25[OH]D) concentration in patients with this condition is lacking. We conducted a multi-centre cross-sectional study in 278 COPD patients aged 41–92 years in London, UK. Details of potential environmental determinants of vitamin D status and COPD symptom control and severity were collected by questionnaire, and blood samples were taken for analysis of serum 25(OH)D concentration and DNA extraction. All participants performed spirometry and underwent measurement of weight and height. Quadriceps muscle strength (QS) was measured in 134 participants, and sputum induction with enumeration of lower airway eosinophil and neutrophil counts was performed for 44 participants. Thirty-seven single nucleotide polymorphisms (SNP) in 11 genes in the vitamin D pathway (DBP, DHCR7, CYP2R1, CYP27B1, CYP24A1, CYP27A1, CYP3A4, LRP2, CUBN, RXRA, and VDR) were typed using Taqman allelic discrimination assays. Linear regression was used to identify environmental and genetic factors independently associated with serum 25(OH)D concentration and to determine whether vitamin D status or genetic factors independently associated with % predicted forced expiratory volume in one second (FEV1), % predicted forced vital capacity (FVC), the ratio of FEV1 to FVC (FEV1:FVC), daily inhaled corticosteroid (ICS) dose, respiratory quality of life (QoL), QS, and the percentage of eosinophils and neutrophils in induced sputum. Mean serum 25(OH)D concentration was 45.4 nmol/L (SD 25.3); 171/278 (61.5%) participants were vitamin D deficient (serum 25[OH]D concentration <50 nmol/L). Lower vitamin D status was independently associated with higher body mass index (P = 0.001), lower socio-economic position (P = 0.037), lack of vitamin D supplement consumption (P < 0.001), sampling in Winter or Spring (P for trend = 0.006) and lack of a recent sunny holiday (P = 0.002). Vitamin D deficiency associated with reduced % predicted FEV1 (P for trend = 0.060) and % predicted FVC (P for trend = 0.003), but it did not associate with FEV1:FVC, ICS dose, QoL, QS, or the percentage of eosinophils or neutrophils in induced sputum. After correction for multiple comparisons testing, genetic variation in the vitamin D pathway was not found to associate with serum 25(OH)D concentration or clinical correlates of COPD severity. Vitamin D deficiency was common in this group of COPD patients in the UK, and it associated independently with reduced % predicted FEV1 and FVC. However, genetic variation in the vitamin D pathway was not associated with vitamin D status or severity of COPD.",
keywords = "Vitamin D, COPD, Single nucleotide polymorphism, Spirometry, FEV1, FVC",
author = "Jolliffe, {David A.} and James, {Wai Yee} and Hooper, {Richard L.} and Barnes, {Neil C.} and Greiller, {Claire L.} and Kamrul Islam and Angshu Bhowmik and Timms, {Peter M.} and Rajakulasingam, {Raj K} and Choudhury, {Aklak B.} and Simcock, {David E.} and Elina Hypp{\"o}nen and Walton, {Robert T.} and Corrigan, {Christopher J.} and Griffiths, {Christopher J.} and Martineau, {Adrian R.}",
year = "2017",
month = feb,
doi = "10.1016/j.jsbmb.2017.01.019",
language = "English",
journal = "Journal of Steroid Biochemistry and Molecular Biology",
issn = "0960-0760",
publisher = "Elsevier Limited",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK

AU - Jolliffe, David A.

AU - James, Wai Yee

AU - Hooper, Richard L.

AU - Barnes, Neil C.

AU - Greiller, Claire L.

AU - Islam, Kamrul

AU - Bhowmik, Angshu

AU - Timms, Peter M.

AU - Rajakulasingam, Raj K

AU - Choudhury, Aklak B.

AU - Simcock, David E.

AU - Hyppönen, Elina

AU - Walton, Robert T.

AU - Corrigan, Christopher J.

AU - Griffiths, Christopher J.

AU - Martineau, Adrian R.

PY - 2017/2

Y1 - 2017/2

N2 - Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD), yet a comprehensive analysis of environmental and genetic determinants of serum 25-hydroxyvitamin D (25[OH]D) concentration in patients with this condition is lacking. We conducted a multi-centre cross-sectional study in 278 COPD patients aged 41–92 years in London, UK. Details of potential environmental determinants of vitamin D status and COPD symptom control and severity were collected by questionnaire, and blood samples were taken for analysis of serum 25(OH)D concentration and DNA extraction. All participants performed spirometry and underwent measurement of weight and height. Quadriceps muscle strength (QS) was measured in 134 participants, and sputum induction with enumeration of lower airway eosinophil and neutrophil counts was performed for 44 participants. Thirty-seven single nucleotide polymorphisms (SNP) in 11 genes in the vitamin D pathway (DBP, DHCR7, CYP2R1, CYP27B1, CYP24A1, CYP27A1, CYP3A4, LRP2, CUBN, RXRA, and VDR) were typed using Taqman allelic discrimination assays. Linear regression was used to identify environmental and genetic factors independently associated with serum 25(OH)D concentration and to determine whether vitamin D status or genetic factors independently associated with % predicted forced expiratory volume in one second (FEV1), % predicted forced vital capacity (FVC), the ratio of FEV1 to FVC (FEV1:FVC), daily inhaled corticosteroid (ICS) dose, respiratory quality of life (QoL), QS, and the percentage of eosinophils and neutrophils in induced sputum. Mean serum 25(OH)D concentration was 45.4 nmol/L (SD 25.3); 171/278 (61.5%) participants were vitamin D deficient (serum 25[OH]D concentration <50 nmol/L). Lower vitamin D status was independently associated with higher body mass index (P = 0.001), lower socio-economic position (P = 0.037), lack of vitamin D supplement consumption (P < 0.001), sampling in Winter or Spring (P for trend = 0.006) and lack of a recent sunny holiday (P = 0.002). Vitamin D deficiency associated with reduced % predicted FEV1 (P for trend = 0.060) and % predicted FVC (P for trend = 0.003), but it did not associate with FEV1:FVC, ICS dose, QoL, QS, or the percentage of eosinophils or neutrophils in induced sputum. After correction for multiple comparisons testing, genetic variation in the vitamin D pathway was not found to associate with serum 25(OH)D concentration or clinical correlates of COPD severity. Vitamin D deficiency was common in this group of COPD patients in the UK, and it associated independently with reduced % predicted FEV1 and FVC. However, genetic variation in the vitamin D pathway was not associated with vitamin D status or severity of COPD.

AB - Vitamin D deficiency is common in patients with chronic obstructive pulmonary disease (COPD), yet a comprehensive analysis of environmental and genetic determinants of serum 25-hydroxyvitamin D (25[OH]D) concentration in patients with this condition is lacking. We conducted a multi-centre cross-sectional study in 278 COPD patients aged 41–92 years in London, UK. Details of potential environmental determinants of vitamin D status and COPD symptom control and severity were collected by questionnaire, and blood samples were taken for analysis of serum 25(OH)D concentration and DNA extraction. All participants performed spirometry and underwent measurement of weight and height. Quadriceps muscle strength (QS) was measured in 134 participants, and sputum induction with enumeration of lower airway eosinophil and neutrophil counts was performed for 44 participants. Thirty-seven single nucleotide polymorphisms (SNP) in 11 genes in the vitamin D pathway (DBP, DHCR7, CYP2R1, CYP27B1, CYP24A1, CYP27A1, CYP3A4, LRP2, CUBN, RXRA, and VDR) were typed using Taqman allelic discrimination assays. Linear regression was used to identify environmental and genetic factors independently associated with serum 25(OH)D concentration and to determine whether vitamin D status or genetic factors independently associated with % predicted forced expiratory volume in one second (FEV1), % predicted forced vital capacity (FVC), the ratio of FEV1 to FVC (FEV1:FVC), daily inhaled corticosteroid (ICS) dose, respiratory quality of life (QoL), QS, and the percentage of eosinophils and neutrophils in induced sputum. Mean serum 25(OH)D concentration was 45.4 nmol/L (SD 25.3); 171/278 (61.5%) participants were vitamin D deficient (serum 25[OH]D concentration <50 nmol/L). Lower vitamin D status was independently associated with higher body mass index (P = 0.001), lower socio-economic position (P = 0.037), lack of vitamin D supplement consumption (P < 0.001), sampling in Winter or Spring (P for trend = 0.006) and lack of a recent sunny holiday (P = 0.002). Vitamin D deficiency associated with reduced % predicted FEV1 (P for trend = 0.060) and % predicted FVC (P for trend = 0.003), but it did not associate with FEV1:FVC, ICS dose, QoL, QS, or the percentage of eosinophils or neutrophils in induced sputum. After correction for multiple comparisons testing, genetic variation in the vitamin D pathway was not found to associate with serum 25(OH)D concentration or clinical correlates of COPD severity. Vitamin D deficiency was common in this group of COPD patients in the UK, and it associated independently with reduced % predicted FEV1 and FVC. However, genetic variation in the vitamin D pathway was not associated with vitamin D status or severity of COPD.

KW - Vitamin D

KW - COPD

KW - Single nucleotide polymorphism

KW - Spirometry

KW - FEV1

KW - FVC

U2 - 10.1016/j.jsbmb.2017.01.019

DO - 10.1016/j.jsbmb.2017.01.019

M3 - Article

JO - Journal of Steroid Biochemistry and Molecular Biology

JF - Journal of Steroid Biochemistry and Molecular Biology

SN - 0960-0760

ER -

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