Prevalence of and association between atopic dermatitis and food sensitivity, food allergy and challenge-proven food allergy: A systematic review and meta-analysis

M. O. Christensen; Y. A. Barakji; N. Loft; C. M. Khatib; A. Egeberg; S. F. Thomsen; J. I. Silverberg; C. Flohr; J. T. Maul; P. Schmid-Grendelmeier; A. S. Halling; I. Vittrup; J. P. Thyssen

doi:10.1111/jdv.18919

Prevalence of and association between atopic dermatitis and food sensitivity, food allergy and challenge-proven food allergy: A systematic review and meta-analysis

M. O. Christensen, Y. A. Barakji, N. Loft, C. M. Khatib, A. Egeberg, S. F. Thomsen, J. I. Silverberg, C. Flohr, J. T. Maul, P. Schmid-Grendelmeier, A. S. Halling, I. Vittrup, J. P. Thyssen^*

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Review article › peer-review

36 Citations (Scopus)

Abstract

Atopic dermatitis (AD) and food allergy (FA) share similar type 2 inflammation and commonly co-occur, but the precise proportion of AD patients with FA and vice versa, as well as the effect of AD disease severity on the strength of this association remains uncertain. The aim of this comprehensive systematic review and meta-analysis was to determine the prevalence and bidirectional associations of AD with food sensitivity (FS), FA and challenge-proven food allergy (CPFA). We searched PubMed and EMBASE and three independent reviewers performed title/abstract and full-text review and data extraction. Overall, 557 articles (n = 225,568 individuals with AD, n = 1,128,322 reference individuals; n = 1,357,793 individuals with FS, FA or CPFA, n = 1,244,596 reference individuals) were included in quantitative analyses. The overall pooled prevalence of FS, FA and CPFA in individuals with AD were 48.4% (95% confidence interval: 43.7–53.2), 32.7% (28.8–36.6) and 40.7% (34.1–47.5) respectively. AD prevalence among individuals with FS, FA and CPFA were 51.2% (46.3–56.2), 45.3% (41.4–49.3) and 54.9% (47.0–62.8) respectively. Children with AD had higher pooled FS (49.8% (44.4–55.1)) and FA (31.4% (26.9–36.1)) prevalences than adults with AD (28.6% (13.4–46.8) and 24.1% (12.1–38.7) respectively). Prevalences of FS and FA numerically increased with AD severity. FS, FA and CPFA are common comorbidities of AD and are closely related. Physicians should be attentive to this relationship to optimize management and treatment strategies in patients.

Original language	English
Pages (from-to)	984-1003
Number of pages	20
Journal	Journal of the European Academy of Dermatology and Venereology
Volume	37
Issue number	5
DOIs	https://doi.org/10.1111/jdv.18919
Publication status	Published - May 2023

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10.1111/jdv.18919

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Christensen, M. O., Barakji, Y. A., Loft, N., Khatib, C. M., Egeberg, A., Thomsen, S. F., Silverberg, J. I., Flohr, C., Maul, J. T., Schmid-Grendelmeier, P., Halling, A. S., Vittrup, I., & Thyssen, J. P. (2023). Prevalence of and association between atopic dermatitis and food sensitivity, food allergy and challenge-proven food allergy: A systematic review and meta-analysis. Journal of the European Academy of Dermatology and Venereology, 37(5), 984-1003. https://doi.org/10.1111/jdv.18919

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title = "Prevalence of and association between atopic dermatitis and food sensitivity, food allergy and challenge-proven food allergy: A systematic review and meta-analysis",

abstract = "Atopic dermatitis (AD) and food allergy (FA) share similar type 2 inflammation and commonly co-occur, but the precise proportion of AD patients with FA and vice versa, as well as the effect of AD disease severity on the strength of this association remains uncertain. The aim of this comprehensive systematic review and meta-analysis was to determine the prevalence and bidirectional associations of AD with food sensitivity (FS), FA and challenge-proven food allergy (CPFA). We searched PubMed and EMBASE and three independent reviewers performed title/abstract and full-text review and data extraction. Overall, 557 articles (n = 225,568 individuals with AD, n = 1,128,322 reference individuals; n = 1,357,793 individuals with FS, FA or CPFA, n = 1,244,596 reference individuals) were included in quantitative analyses. The overall pooled prevalence of FS, FA and CPFA in individuals with AD were 48.4% (95% confidence interval: 43.7–53.2), 32.7% (28.8–36.6) and 40.7% (34.1–47.5) respectively. AD prevalence among individuals with FS, FA and CPFA were 51.2% (46.3–56.2), 45.3% (41.4–49.3) and 54.9% (47.0–62.8) respectively. Children with AD had higher pooled FS (49.8% (44.4–55.1)) and FA (31.4% (26.9–36.1)) prevalences than adults with AD (28.6% (13.4–46.8) and 24.1% (12.1–38.7) respectively). Prevalences of FS and FA numerically increased with AD severity. FS, FA and CPFA are common comorbidities of AD and are closely related. Physicians should be attentive to this relationship to optimize management and treatment strategies in patients.",

author = "Christensen, {M. O.} and Barakji, {Y. A.} and N. Loft and Khatib, {C. M.} and A. Egeberg and Thomsen, {S. F.} and Silverberg, {J. I.} and C. Flohr and Maul, {J. T.} and P. Schmid-Grendelmeier and Halling, {A. S.} and I. Vittrup and Thyssen, {J. P.}",

note = "Funding Information: Dr Thyssen is supported by an unrestricted grant from the Lundbeck Foundation. Publisher Copyright: {\textcopyright} 2023 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.",

year = "2023",

month = may,

doi = "10.1111/jdv.18919",

language = "English",

volume = "37",

pages = "984--1003",

journal = "Journal of the European Academy of Dermatology and Venereology",

issn = "0926-9959",

publisher = "Wiley",

number = "5",

}

Christensen, MO, Barakji, YA, Loft, N, Khatib, CM, Egeberg, A, Thomsen, SF, Silverberg, JI, Flohr, C, Maul, JT, Schmid-Grendelmeier, P, Halling, AS, Vittrup, I & Thyssen, JP 2023, 'Prevalence of and association between atopic dermatitis and food sensitivity, food allergy and challenge-proven food allergy: A systematic review and meta-analysis', Journal of the European Academy of Dermatology and Venereology, vol. 37, no. 5, pp. 984-1003. https://doi.org/10.1111/jdv.18919

Prevalence of and association between atopic dermatitis and food sensitivity, food allergy and challenge-proven food allergy: A systematic review and meta-analysis. / Christensen, M. O.; Barakji, Y. A.; Loft, N. et al.
In: Journal of the European Academy of Dermatology and Venereology, Vol. 37, No. 5, 05.2023, p. 984-1003.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Prevalence of and association between atopic dermatitis and food sensitivity, food allergy and challenge-proven food allergy

T2 - A systematic review and meta-analysis

AU - Christensen, M. O.

AU - Barakji, Y. A.

AU - Loft, N.

AU - Khatib, C. M.

AU - Egeberg, A.

AU - Thomsen, S. F.

AU - Silverberg, J. I.

AU - Flohr, C.

AU - Maul, J. T.

AU - Schmid-Grendelmeier, P.

AU - Halling, A. S.

AU - Vittrup, I.

AU - Thyssen, J. P.

N1 - Funding Information: Dr Thyssen is supported by an unrestricted grant from the Lundbeck Foundation. Publisher Copyright: © 2023 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.

PY - 2023/5

Y1 - 2023/5

N2 - Atopic dermatitis (AD) and food allergy (FA) share similar type 2 inflammation and commonly co-occur, but the precise proportion of AD patients with FA and vice versa, as well as the effect of AD disease severity on the strength of this association remains uncertain. The aim of this comprehensive systematic review and meta-analysis was to determine the prevalence and bidirectional associations of AD with food sensitivity (FS), FA and challenge-proven food allergy (CPFA). We searched PubMed and EMBASE and three independent reviewers performed title/abstract and full-text review and data extraction. Overall, 557 articles (n = 225,568 individuals with AD, n = 1,128,322 reference individuals; n = 1,357,793 individuals with FS, FA or CPFA, n = 1,244,596 reference individuals) were included in quantitative analyses. The overall pooled prevalence of FS, FA and CPFA in individuals with AD were 48.4% (95% confidence interval: 43.7–53.2), 32.7% (28.8–36.6) and 40.7% (34.1–47.5) respectively. AD prevalence among individuals with FS, FA and CPFA were 51.2% (46.3–56.2), 45.3% (41.4–49.3) and 54.9% (47.0–62.8) respectively. Children with AD had higher pooled FS (49.8% (44.4–55.1)) and FA (31.4% (26.9–36.1)) prevalences than adults with AD (28.6% (13.4–46.8) and 24.1% (12.1–38.7) respectively). Prevalences of FS and FA numerically increased with AD severity. FS, FA and CPFA are common comorbidities of AD and are closely related. Physicians should be attentive to this relationship to optimize management and treatment strategies in patients.

AB - Atopic dermatitis (AD) and food allergy (FA) share similar type 2 inflammation and commonly co-occur, but the precise proportion of AD patients with FA and vice versa, as well as the effect of AD disease severity on the strength of this association remains uncertain. The aim of this comprehensive systematic review and meta-analysis was to determine the prevalence and bidirectional associations of AD with food sensitivity (FS), FA and challenge-proven food allergy (CPFA). We searched PubMed and EMBASE and three independent reviewers performed title/abstract and full-text review and data extraction. Overall, 557 articles (n = 225,568 individuals with AD, n = 1,128,322 reference individuals; n = 1,357,793 individuals with FS, FA or CPFA, n = 1,244,596 reference individuals) were included in quantitative analyses. The overall pooled prevalence of FS, FA and CPFA in individuals with AD were 48.4% (95% confidence interval: 43.7–53.2), 32.7% (28.8–36.6) and 40.7% (34.1–47.5) respectively. AD prevalence among individuals with FS, FA and CPFA were 51.2% (46.3–56.2), 45.3% (41.4–49.3) and 54.9% (47.0–62.8) respectively. Children with AD had higher pooled FS (49.8% (44.4–55.1)) and FA (31.4% (26.9–36.1)) prevalences than adults with AD (28.6% (13.4–46.8) and 24.1% (12.1–38.7) respectively). Prevalences of FS and FA numerically increased with AD severity. FS, FA and CPFA are common comorbidities of AD and are closely related. Physicians should be attentive to this relationship to optimize management and treatment strategies in patients.

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DO - 10.1111/jdv.18919

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SN - 0926-9959

VL - 37

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JO - Journal of the European Academy of Dermatology and Venereology

JF - Journal of the European Academy of Dermatology and Venereology

IS - 5

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Prevalence of and association between atopic dermatitis and food sensitivity, food allergy and challenge-proven food allergy: A systematic review and meta-analysis

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