Prevalence of dementia in Latin America, India, and China: a population-based cross-sectional survey

Juan J. Llibre Rodriguez; Cleusa P. Ferri; Daisy Acosta; Mariella Guerra; Yueqin Huang; K. S. Jacob; E. S. Krishnamoorthy; Aquiles Salas; Ana Luisa Sosa; Isaac Acosta; Michael E. Dewey; Ciro Gaona; A. T. Jotheeswaran; Shuran Li; Diana Rodriguez; Guillermina Rodriguez; P. Senthil Kumar; Adolfo Valhuerdi; Martin Prince; 10-66 Dementia Res Grp

doi:10.1016/S0140-6736(08)61002-8

Prevalence of dementia in Latin America, India, and China: a population-based cross-sectional survey

Juan J. Llibre Rodriguez, Cleusa P. Ferri, Daisy Acosta, Mariella Guerra, Yueqin Huang, K. S. Jacob, E. S. Krishnamoorthy, Aquiles Salas, Ana Luisa Sosa, Isaac Acosta, Michael E. Dewey, Ciro Gaona, A. T. Jotheeswaran, Shuran Li, Diana Rodriguez, Guillermina Rodriguez, P. Senthil Kumar, Adolfo Valhuerdi, Martin Prince, 10-66 Dementia Res Grp

Research output: Contribution to journal › Article › peer-review

348 Citations (Scopus)

Abstract

Background Studies have suggested that the prevalence of dementia is lower in developing than in developed regions. We investigated the prevalence and severity of dementia in sites in low-income and middle-income countries according to two definitions of dementia diagnosis.

Methods We undertook one-phase cross-sectional surveys of all residents aged 65 years and older (n=14 960) in 11 sites in seven low-income and middle-income countries (China, India, Cuba, Dominican Republic, Venezuela, Mexico, and Peru). Dementia diagnosis was made according to the culturally and educationally sensitive, 10/66 dementia diagnostic algorithm, which had been prevalidated in 25 Latin American, Asian, and African centres; and by computerised application of the dementia criterion from the Diagnostic and Statistical Manual of Mental Disorders (DSM IV). We also compared prevalence of DSM-IV dementia in each of the study sites with that from estimates in European studies.

Findings The prevalence of DSM-IV dementia varied widely, from 0.3% (95% CI 0.1-0.5) in rural India to 6.3% (5.0-7.7) in Cuba. After standardisation for age and sex, DSM-IV prevalence in urban Latin American sites was four-fifths of that in Europe (standardised morbidity ratio 80 [95% CI 70-91]), but in China the prevalence was only half (56 [32-91] in rural China), and in India and rural Latin America a quarter or less of the European prevalence (18 [5-34] in rural India). 10/66 dementia prevalence was higher than that of DSM-IV dementia, and more consistent across sites, varying between 5.6% (95% CI 4.2-7.0) in rural China and 11.7% (10.3-13.1) in the Dominican Republic. The validity of the 847 of 1345 cases of 10/66 dementia not confirmed by DSM-IV was supported by high levels of associated disability (mean WHO Disability Assessment Schedule II score 33.7 [SD 28.6]).

Interpretation As compared with the 10/66 dementia algorithm, the DSM-IV dementia criterion might underestimate dementia prevalence, especially in regions with low awareness of this emerging public-health problem.

Funding Wellcome Trust (UK); WHO; the US Alzheimer's Association; and Fondo Nacional De Ciencia, Y Tecnologia, Consejo De Desarrollo Cientifico Y Humanistico, and Universidad Central De Venezuela (Venezuela).

Original language	English
Pages (from-to)	464-474
Number of pages	11
Journal	The Lancet
Volume	372
Issue number	9637
DOIs	https://doi.org/10.1016/S0140-6736(08)61002-8
Publication status	Published - 9 Aug 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0140-6736(08)61002-8

Cite this

Rodriguez, J. J. L., Ferri, C. P., Acosta, D., Guerra, M., Huang, Y., Jacob, K. S., Krishnamoorthy, E. S., Salas, A., Sosa, A. L., Acosta, I., Dewey, M. E., Gaona, C., Jotheeswaran, A. T., Li, S., Rodriguez, D., Rodriguez, G., Kumar, P. S., Valhuerdi, A., Prince, M., & 10-66 Dementia Res Grp (2008). Prevalence of dementia in Latin America, India, and China: a population-based cross-sectional survey. The Lancet, 372(9637), 464-474. https://doi.org/10.1016/S0140-6736(08)61002-8

@article{471fe224651b4a9c8662d1b7266e5737,

title = "Prevalence of dementia in Latin America, India, and China: a population-based cross-sectional survey",

abstract = "Background Studies have suggested that the prevalence of dementia is lower in developing than in developed regions. We investigated the prevalence and severity of dementia in sites in low-income and middle-income countries according to two definitions of dementia diagnosis.Methods We undertook one-phase cross-sectional surveys of all residents aged 65 years and older (n=14 960) in 11 sites in seven low-income and middle-income countries (China, India, Cuba, Dominican Republic, Venezuela, Mexico, and Peru). Dementia diagnosis was made according to the culturally and educationally sensitive, 10/66 dementia diagnostic algorithm, which had been prevalidated in 25 Latin American, Asian, and African centres; and by computerised application of the dementia criterion from the Diagnostic and Statistical Manual of Mental Disorders (DSM IV). We also compared prevalence of DSM-IV dementia in each of the study sites with that from estimates in European studies.Findings The prevalence of DSM-IV dementia varied widely, from 0.3% (95% CI 0.1-0.5) in rural India to 6.3% (5.0-7.7) in Cuba. After standardisation for age and sex, DSM-IV prevalence in urban Latin American sites was four-fifths of that in Europe (standardised morbidity ratio 80 [95% CI 70-91]), but in China the prevalence was only half (56 [32-91] in rural China), and in India and rural Latin America a quarter or less of the European prevalence (18 [5-34] in rural India). 10/66 dementia prevalence was higher than that of DSM-IV dementia, and more consistent across sites, varying between 5.6% (95% CI 4.2-7.0) in rural China and 11.7% (10.3-13.1) in the Dominican Republic. The validity of the 847 of 1345 cases of 10/66 dementia not confirmed by DSM-IV was supported by high levels of associated disability (mean WHO Disability Assessment Schedule II score 33.7 [SD 28.6]).Interpretation As compared with the 10/66 dementia algorithm, the DSM-IV dementia criterion might underestimate dementia prevalence, especially in regions with low awareness of this emerging public-health problem.Funding Wellcome Trust (UK); WHO; the US Alzheimer's Association; and Fondo Nacional De Ciencia, Y Tecnologia, Consejo De Desarrollo Cientifico Y Humanistico, and Universidad Central De Venezuela (Venezuela).",

author = "Rodriguez, {Juan J. Llibre} and Ferri, {Cleusa P.} and Daisy Acosta and Mariella Guerra and Yueqin Huang and Jacob, {K. S.} and Krishnamoorthy, {E. S.} and Aquiles Salas and Sosa, {Ana Luisa} and Isaac Acosta and Dewey, {Michael E.} and Ciro Gaona and Jotheeswaran, {A. T.} and Shuran Li and Diana Rodriguez and Guillermina Rodriguez and Kumar, {P. Senthil} and Adolfo Valhuerdi and Martin Prince and {10-66 Dementia Res Grp}",

year = "2008",

month = aug,

day = "9",

doi = "10.1016/S0140-6736(08)61002-8",

language = "English",

volume = "372",

pages = "464--474",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier B.V.",

number = "9637",

}

Rodriguez, JJL, Ferri, CP, Acosta, D, Guerra, M, Huang, Y, Jacob, KS, Krishnamoorthy, ES, Salas, A, Sosa, AL, Acosta, I, Dewey, ME, Gaona, C, Jotheeswaran, AT, Li, S, Rodriguez, D, Rodriguez, G, Kumar, PS, Valhuerdi, A, Prince, M & 10-66 Dementia Res Grp 2008, 'Prevalence of dementia in Latin America, India, and China: a population-based cross-sectional survey', The Lancet, vol. 372, no. 9637, pp. 464-474. https://doi.org/10.1016/S0140-6736(08)61002-8

TY - JOUR

T1 - Prevalence of dementia in Latin America, India, and China: a population-based cross-sectional survey

AU - Rodriguez, Juan J. Llibre

AU - Ferri, Cleusa P.

AU - Acosta, Daisy

AU - Guerra, Mariella

AU - Huang, Yueqin

AU - Jacob, K. S.

AU - Krishnamoorthy, E. S.

AU - Salas, Aquiles

AU - Sosa, Ana Luisa

AU - Acosta, Isaac

AU - Dewey, Michael E.

AU - Gaona, Ciro

AU - Jotheeswaran, A. T.

AU - Li, Shuran

AU - Rodriguez, Diana

AU - Rodriguez, Guillermina

AU - Kumar, P. Senthil

AU - Valhuerdi, Adolfo

AU - Prince, Martin

AU - 10-66 Dementia Res Grp

PY - 2008/8/9

Y1 - 2008/8/9

N2 - Background Studies have suggested that the prevalence of dementia is lower in developing than in developed regions. We investigated the prevalence and severity of dementia in sites in low-income and middle-income countries according to two definitions of dementia diagnosis.Methods We undertook one-phase cross-sectional surveys of all residents aged 65 years and older (n=14 960) in 11 sites in seven low-income and middle-income countries (China, India, Cuba, Dominican Republic, Venezuela, Mexico, and Peru). Dementia diagnosis was made according to the culturally and educationally sensitive, 10/66 dementia diagnostic algorithm, which had been prevalidated in 25 Latin American, Asian, and African centres; and by computerised application of the dementia criterion from the Diagnostic and Statistical Manual of Mental Disorders (DSM IV). We also compared prevalence of DSM-IV dementia in each of the study sites with that from estimates in European studies.Findings The prevalence of DSM-IV dementia varied widely, from 0.3% (95% CI 0.1-0.5) in rural India to 6.3% (5.0-7.7) in Cuba. After standardisation for age and sex, DSM-IV prevalence in urban Latin American sites was four-fifths of that in Europe (standardised morbidity ratio 80 [95% CI 70-91]), but in China the prevalence was only half (56 [32-91] in rural China), and in India and rural Latin America a quarter or less of the European prevalence (18 [5-34] in rural India). 10/66 dementia prevalence was higher than that of DSM-IV dementia, and more consistent across sites, varying between 5.6% (95% CI 4.2-7.0) in rural China and 11.7% (10.3-13.1) in the Dominican Republic. The validity of the 847 of 1345 cases of 10/66 dementia not confirmed by DSM-IV was supported by high levels of associated disability (mean WHO Disability Assessment Schedule II score 33.7 [SD 28.6]).Interpretation As compared with the 10/66 dementia algorithm, the DSM-IV dementia criterion might underestimate dementia prevalence, especially in regions with low awareness of this emerging public-health problem.Funding Wellcome Trust (UK); WHO; the US Alzheimer's Association; and Fondo Nacional De Ciencia, Y Tecnologia, Consejo De Desarrollo Cientifico Y Humanistico, and Universidad Central De Venezuela (Venezuela).

AB - Background Studies have suggested that the prevalence of dementia is lower in developing than in developed regions. We investigated the prevalence and severity of dementia in sites in low-income and middle-income countries according to two definitions of dementia diagnosis.Methods We undertook one-phase cross-sectional surveys of all residents aged 65 years and older (n=14 960) in 11 sites in seven low-income and middle-income countries (China, India, Cuba, Dominican Republic, Venezuela, Mexico, and Peru). Dementia diagnosis was made according to the culturally and educationally sensitive, 10/66 dementia diagnostic algorithm, which had been prevalidated in 25 Latin American, Asian, and African centres; and by computerised application of the dementia criterion from the Diagnostic and Statistical Manual of Mental Disorders (DSM IV). We also compared prevalence of DSM-IV dementia in each of the study sites with that from estimates in European studies.Findings The prevalence of DSM-IV dementia varied widely, from 0.3% (95% CI 0.1-0.5) in rural India to 6.3% (5.0-7.7) in Cuba. After standardisation for age and sex, DSM-IV prevalence in urban Latin American sites was four-fifths of that in Europe (standardised morbidity ratio 80 [95% CI 70-91]), but in China the prevalence was only half (56 [32-91] in rural China), and in India and rural Latin America a quarter or less of the European prevalence (18 [5-34] in rural India). 10/66 dementia prevalence was higher than that of DSM-IV dementia, and more consistent across sites, varying between 5.6% (95% CI 4.2-7.0) in rural China and 11.7% (10.3-13.1) in the Dominican Republic. The validity of the 847 of 1345 cases of 10/66 dementia not confirmed by DSM-IV was supported by high levels of associated disability (mean WHO Disability Assessment Schedule II score 33.7 [SD 28.6]).Interpretation As compared with the 10/66 dementia algorithm, the DSM-IV dementia criterion might underestimate dementia prevalence, especially in regions with low awareness of this emerging public-health problem.Funding Wellcome Trust (UK); WHO; the US Alzheimer's Association; and Fondo Nacional De Ciencia, Y Tecnologia, Consejo De Desarrollo Cientifico Y Humanistico, and Universidad Central De Venezuela (Venezuela).

U2 - 10.1016/S0140-6736(08)61002-8

DO - 10.1016/S0140-6736(08)61002-8

M3 - Article

SN - 0140-6736

VL - 372

SP - 464

EP - 474

JO - The Lancet

JF - The Lancet

IS - 9637

ER -

Prevalence of dementia in Latin America, India, and China: a population-based cross-sectional survey

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this