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Prevalence of serum N-methyl-D-aspartate receptor autoantibodies in refractory psychosis

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)164-165
Number of pages2
JournalBritish Journal of Psychiatry
Volume206
Issue number2
DOIs
StatePublished - 1 Feb 2015

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Abstract

N-methyl-D-aspartate receptor (NMDA-R) autoantibodies have been reported in people with acute psychosis. We hypothesised that their presence may be implicated in the aetiology of treatment-refractory psychosis. We sought to ascertain the point prevalence of NMDA-R antibody positivity in patients referred to services for treatment-refractory psychosis. We found that 3 (7.0%) of 43 individuals had low positive NMDA-R antibody titres. This suggests that NMDA-R autoantibodies are unlikely to account for a large proportion of treatment-refractory psychosis.

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