Prevention of mucosally induced uveitis with a HSP60-derived peptide linked to cholera toxin B subunit

P A Phipps, M R Stanford, J B Sun, B G Xiao, J Holmgren, T Shinnick, A Hasan, Y Mizushima, T Lehner

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72 Citations (Scopus)

Abstract

Oral administration of the uveitogenic peptide (aa 336-351) derived from human HSP60 induced clinical and histological manifestations of uveitis in 65.8% (48/73) of Lewis rats. Uveitis was significantly decreased to 16.7% (11/66) in parallel experiments with the peptide linked to recombinant cholera toxin B subunit (rCTB), also given by mouth (x(2) = 34.2, p
Original languageEnglish
Pages (from-to)224 - 232
Number of pages9
JournalEuropean Journal of Immunology
Volume33
Issue number1
DOIs
Publication statusPublished - 1 Jan 2003

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