Principles of haemopoietic stem cell transplantation

Robin Dowse; Donal P. McLornan

doi:10.1016/j.mpmed.2017.02.009

Principles of haemopoietic stem cell transplantation

Robin Dowse, Donal P. McLornan

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Rapid developments within the field of stem cell transplantation have occurred over the last few decades. Improvements in conditioning regimens coupled with advances in supportive and anti-infective care have correlated, in general, with improved survival compared with historical cohorts. Increasing use of alternative donor sources, such as umbilical cord blood and haploidentical stem cells, has permitted more patients without a matched sibling or well-matched unrelated donor to proceed with allogeneic transplantation as a therapeutic modality. Within this short review, the main indications for both autologous and allogeneic stem cell transplantations are highlighted. There is a focus on stem cell harvesting and graft-versus-host disease, and key areas of current research focus are highlighted.

Original language	English
Journal	Medicine
DOIs	https://doi.org/10.1016/j.mpmed.2017.02.009
Publication status	E-pub ahead of print - 22 Mar 2017

Keywords

Apheresis
GVHD
haploidentical
immunotherapy
stem cell transplant

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10.1016/j.mpmed.2017.02.009

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title = "Principles of haemopoietic stem cell transplantation",

abstract = "Rapid developments within the field of stem cell transplantation have occurred over the last few decades. Improvements in conditioning regimens coupled with advances in supportive and anti-infective care have correlated, in general, with improved survival compared with historical cohorts. Increasing use of alternative donor sources, such as umbilical cord blood and haploidentical stem cells, has permitted more patients without a matched sibling or well-matched unrelated donor to proceed with allogeneic transplantation as a therapeutic modality. Within this short review, the main indications for both autologous and allogeneic stem cell transplantations are highlighted. There is a focus on stem cell harvesting and graft-versus-host disease, and key areas of current research focus are highlighted.",

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AU - Dowse, Robin

AU - McLornan, Donal P.

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AB - Rapid developments within the field of stem cell transplantation have occurred over the last few decades. Improvements in conditioning regimens coupled with advances in supportive and anti-infective care have correlated, in general, with improved survival compared with historical cohorts. Increasing use of alternative donor sources, such as umbilical cord blood and haploidentical stem cells, has permitted more patients without a matched sibling or well-matched unrelated donor to proceed with allogeneic transplantation as a therapeutic modality. Within this short review, the main indications for both autologous and allogeneic stem cell transplantations are highlighted. There is a focus on stem cell harvesting and graft-versus-host disease, and key areas of current research focus are highlighted.

KW - Apheresis

KW - GVHD

KW - haploidentical

KW - immunotherapy

KW - stem cell transplant

U2 - 10.1016/j.mpmed.2017.02.009

DO - 10.1016/j.mpmed.2017.02.009

M3 - Article

SN - 1357-3039

JO - Medicine

JF - Medicine

ER -

Principles of haemopoietic stem cell transplantation

Abstract

Keywords

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