Probabilistic Interpolation of Uncertain Local Activation Times on Human Atrial Manifolds

Sam Coveney; Cesare Corrado; Caroline Roney; Richard Wilkinson; Jeremy Oakley; Finn Lindgren; Steven Williams; Mark D O'Neill; Steven Niederer; Richard Clayton

doi:10.1109/TBME.2019.2908486

Probabilistic Interpolation of Uncertain Local Activation Times on Human Atrial Manifolds

Sam Coveney, Cesare Corrado, Caroline Roney, Richard Wilkinson, Jeremy Oakley, Finn Lindgren, Steven Williams, Mark D O'Neill, Steven Niederer, Richard Clayton

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Local activation time (LAT) mapping of the atria is important for targeted treatment of atrial arrhythmias, but current methods do not interpolate on the atrial manifold and neglect uncertainties associated with LAT observations. In this paper, we describe novel methods to, first, quantify uncertainties in LAT arising from bipolar electrogram analysis and assignment of electrode recordings to the anatomical mesh, second, interpolate uncertain LAT measurements directly on left atrial manifolds to obtain complete probabilistic activation maps, and finally, interpolate LAT jointly across both the manifold and different S1-S2 pacing protocols. Methods: A modified center of mass approach was used to process bipolar electrograms, yielding a LAT estimate and error distribution from the electrogram morphology. An error distribution for assigning measurements to the anatomical mesh was estimated. Probabilistic LAT maps were produced by interpolating on a left atrial manifold using Gaussian Markov random fields, taking into account observation errors and characterizing LAT predictions by their mean and standard deviation. This approach was extended to interpolate across S1-S2 pacing protocols. Results: We evaluated our approach using recordings from three patients undergoing atrial ablation. Cross-validation showed consistent and accurate prediction of LAT observations both at different locations on the left atrium and for different S1-S2 intervals. Significance: Interpolation of scalar and vector fields across anatomical structures from point measurements is a challenging problem in biomedical engineering, compounded by uncertainties in measurements and meshes. New methods and approaches are required, and in this paper, we have demonstrated an effective method for probabilistic interpolation of uncertain LAT.

Original language	English
Article number	8684876
Pages (from-to)	99-109
Number of pages	11
Journal	IEEE Transactions on Biomedical Engineering
Volume	67
Issue number	1
Early online date	9 Apr 2019
DOIs	https://doi.org/10.1109/TBME.2019.2908486
Publication status	Published - 1 Jan 2020

Keywords

Bipolar electrogram
atrial fibrillation
local activation time
probabilistic interpolation
uncertainty

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10.1109/TBME.2019.2908486

https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=8684876Licence: CC BY

Cite this

@article{ae84fc86589040a4a4ee30e74ed6898f,

title = "Probabilistic Interpolation of Uncertain Local Activation Times on Human Atrial Manifolds",

abstract = "Local activation time (LAT) mapping of the atria is important for targeted treatment of atrial arrhythmias, but current methods do not interpolate on the atrial manifold and neglect uncertainties associated with LAT observations. In this paper, we describe novel methods to, first, quantify uncertainties in LAT arising from bipolar electrogram analysis and assignment of electrode recordings to the anatomical mesh, second, interpolate uncertain LAT measurements directly on left atrial manifolds to obtain complete probabilistic activation maps, and finally, interpolate LAT jointly across both the manifold and different S1-S2 pacing protocols. Methods: A modified center of mass approach was used to process bipolar electrograms, yielding a LAT estimate and error distribution from the electrogram morphology. An error distribution for assigning measurements to the anatomical mesh was estimated. Probabilistic LAT maps were produced by interpolating on a left atrial manifold using Gaussian Markov random fields, taking into account observation errors and characterizing LAT predictions by their mean and standard deviation. This approach was extended to interpolate across S1-S2 pacing protocols. Results: We evaluated our approach using recordings from three patients undergoing atrial ablation. Cross-validation showed consistent and accurate prediction of LAT observations both at different locations on the left atrium and for different S1-S2 intervals. Significance: Interpolation of scalar and vector fields across anatomical structures from point measurements is a challenging problem in biomedical engineering, compounded by uncertainties in measurements and meshes. New methods and approaches are required, and in this paper, we have demonstrated an effective method for probabilistic interpolation of uncertain LAT.",

keywords = "Bipolar electrogram, atrial fibrillation, local activation time, probabilistic interpolation, uncertainty",

author = "Sam Coveney and Cesare Corrado and Caroline Roney and Richard Wilkinson and Jeremy Oakley and Finn Lindgren and Steven Williams and O'Neill, {Mark D} and Steven Niederer and Richard Clayton",

year = "2020",

month = jan,

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doi = "10.1109/TBME.2019.2908486",

language = "English",

volume = "67",

pages = "99--109",

journal = "IEEE Transactions on Biomedical Engineering",

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T1 - Probabilistic Interpolation of Uncertain Local Activation Times on Human Atrial Manifolds

AU - Coveney, Sam

AU - Corrado, Cesare

AU - Roney, Caroline

AU - Wilkinson, Richard

AU - Oakley, Jeremy

AU - Lindgren, Finn

AU - Williams, Steven

AU - O'Neill, Mark D

AU - Niederer, Steven

AU - Clayton, Richard

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Local activation time (LAT) mapping of the atria is important for targeted treatment of atrial arrhythmias, but current methods do not interpolate on the atrial manifold and neglect uncertainties associated with LAT observations. In this paper, we describe novel methods to, first, quantify uncertainties in LAT arising from bipolar electrogram analysis and assignment of electrode recordings to the anatomical mesh, second, interpolate uncertain LAT measurements directly on left atrial manifolds to obtain complete probabilistic activation maps, and finally, interpolate LAT jointly across both the manifold and different S1-S2 pacing protocols. Methods: A modified center of mass approach was used to process bipolar electrograms, yielding a LAT estimate and error distribution from the electrogram morphology. An error distribution for assigning measurements to the anatomical mesh was estimated. Probabilistic LAT maps were produced by interpolating on a left atrial manifold using Gaussian Markov random fields, taking into account observation errors and characterizing LAT predictions by their mean and standard deviation. This approach was extended to interpolate across S1-S2 pacing protocols. Results: We evaluated our approach using recordings from three patients undergoing atrial ablation. Cross-validation showed consistent and accurate prediction of LAT observations both at different locations on the left atrium and for different S1-S2 intervals. Significance: Interpolation of scalar and vector fields across anatomical structures from point measurements is a challenging problem in biomedical engineering, compounded by uncertainties in measurements and meshes. New methods and approaches are required, and in this paper, we have demonstrated an effective method for probabilistic interpolation of uncertain LAT.

AB - Local activation time (LAT) mapping of the atria is important for targeted treatment of atrial arrhythmias, but current methods do not interpolate on the atrial manifold and neglect uncertainties associated with LAT observations. In this paper, we describe novel methods to, first, quantify uncertainties in LAT arising from bipolar electrogram analysis and assignment of electrode recordings to the anatomical mesh, second, interpolate uncertain LAT measurements directly on left atrial manifolds to obtain complete probabilistic activation maps, and finally, interpolate LAT jointly across both the manifold and different S1-S2 pacing protocols. Methods: A modified center of mass approach was used to process bipolar electrograms, yielding a LAT estimate and error distribution from the electrogram morphology. An error distribution for assigning measurements to the anatomical mesh was estimated. Probabilistic LAT maps were produced by interpolating on a left atrial manifold using Gaussian Markov random fields, taking into account observation errors and characterizing LAT predictions by their mean and standard deviation. This approach was extended to interpolate across S1-S2 pacing protocols. Results: We evaluated our approach using recordings from three patients undergoing atrial ablation. Cross-validation showed consistent and accurate prediction of LAT observations both at different locations on the left atrium and for different S1-S2 intervals. Significance: Interpolation of scalar and vector fields across anatomical structures from point measurements is a challenging problem in biomedical engineering, compounded by uncertainties in measurements and meshes. New methods and approaches are required, and in this paper, we have demonstrated an effective method for probabilistic interpolation of uncertain LAT.

KW - Bipolar electrogram

KW - atrial fibrillation

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ER -

Probabilistic Interpolation of Uncertain Local Activation Times on Human Atrial Manifolds

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