Probing the Mobilome: Discoveries in the Dynamic Microbiome

Dave Moyes, Vicky Carr, peter Mullany, Colin Hill, Andrey Shkoporov

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)

Abstract

There has been an explosion of metagenomic data representing human, animal,and environmental microbiomes. This provides an unprecedented opportunityfor comparative and longitudinal studies of many functional aspects of themicrobiome that go beyond taxonomic classification, such as profiling geneticdeterminants of antimicrobial resistance, interactions with the host, potentiallyclinically relevant functions, and the role of mobile genetic elements (MGEs).One of the most important but least studied of these aspects are the MGEs, col-lectively referred to as the 'mobilome'. Here we elaborate on the benefits and lim-itations of using different metagenomic protocols, discuss the relative merits ofvarious sequencing technologies, and highlight relevant bioinformatics toolsand pipelines to predict the presence of MGEs and their microbial hosts.
Original languageEnglish
JournalTrends in Microbiology
Early online date10 May 2020
DOIs
Publication statusE-pub ahead of print - 10 May 2020

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