Probiotics in irritable bowel syndrome and inflammatory bowel disease review of mechanisms and effectiveness

Daniel So, Eamonn M M Quigley, Kevin Whelan

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: The gastrointestinal (GI) microbiome has been implicated in the pathogenesis of inflammatory bowel disease (IBD) and has been linked with irritable bowel syndrome (IBS). The aim of this article is to critically review the emerging evidence for the mechanisms and effectiveness of probiotics in the management of these conditions.

RECENT FINDINGS: The GI microbiome is strongly influenced by ageing, diet and disease. Probiotics may confer health effects to the host by modulating the metabolic activities of the microbiome to propagate anti-inflammatory effects and reinforce the intestinal barrier, and are considered to be safe to use. Many short-term studies have demonstrated the effectiveness of probiotics overall in IBS, with meta-analyses demonstrating efficacy across specific strains albeit with relatively small effect sizes. Within IBD, some probiotics appear to offer clinical benefit in ulcerative colitis but strain-specific effects are unclear. Evidence for the use of probiotics in Crohn's disease remains limited.

SUMMARY: Probiotics offer considerable potential for the management of IBS and possibly in IBD, however, any benefits conferred appear to be strain-specific. High quality trials of specific probiotics in IBS and IBD, as well as laboratory investigations of their mechanism of action, are required in order to fully understand their potential therapeutic value.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalCURRENT OPINION IN GASTROENTEROLOGY
Volume39
Issue number2
DOIs
Publication statusAccepted/In press - 16 Dec 2022

Keywords

  • Humans
  • Irritable Bowel Syndrome/therapy
  • Inflammatory Bowel Diseases/drug therapy
  • Probiotics/therapeutic use
  • Intestines
  • Crohn Disease

Fingerprint

Dive into the research topics of 'Probiotics in irritable bowel syndrome and inflammatory bowel disease review of mechanisms and effectiveness'. Together they form a unique fingerprint.

Cite this