Prognostic Factors for Mental Wellbeing in Prostate Cancer: A Systematic Review and Meta-Analysis

Neel Vyas, Oliver Brunckhorst*, Jack Fanshawe, Robert Stewart, Prokar Dasgupta, Kamran Ahmed

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


To evaluate the evidence base for patient, oncological and treatment prognostic factors associated with multiple mental wellbeing outcomes in prostate cancer patients.

We performed a literature search of MEDLINE, EMBASE and CINAHL databases including studies evaluating patient, oncological, or treatment factors against one of five mental wellbeing outcomes; depression, anxiety, fear of cancer recurrence, masculinity, and body image perception. Data synthesis included a random effects meta-analysis for the prognostic effect of individual factors if sufficient homogenous data was available, with a structured narrative synthesis where this was not possible.

A final 62 articles were included. Older age was associated with a reducing odds of depression (OR 0.97, p=0.04), with little evidence of effect for other outcomes. Additionally, mental health status was related to depression and increasing time since diagnosis was associated with reducing fear of recurrence, albeith with low certainty of evidence. However, few other patient or oncological factors demonstrated any coherent relationship with any wellbeing outcome. Androgen deprivation therapy was associated with increased depression (HR 1.65, 95% CI 1.41-1.92, p
We highlight the existing evidence for prognostic factors in mental wellbeing outcomes in prostate cancer, allowing us to consider high-risk groups of patients for preventative and treatment measures. However, the current evidence is heterogenous with further work required exploring less conclusive factors and outcomes.
Original languageEnglish
Publication statusAccepted/In press - 18 Sept 2023


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