Programmed cell death: central player in fungal infections

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Abstract

Fungal diseases contribute significantly to morbidity and mortality in humans.
Although recent research has improved our understanding of the complex and
dynamic interplay that occurs between pathogenic fungi and the human host,
much remains to be elucidated concerning the molecular mechanisms that
drive fungal pathogenicity and host responses to fungal infections. In recent
times, there has been a significant increase in studies investigating the immunological functions of microbial-induced host cell death. In addition, pathogens use
many strategies to manipulate host cell death pathways to facilitate their survival
and dissemination. This review will focus on the mechanisms of host programmed
cell death that occur during opportunistic fungal infections, and explore how cell
death pathways may affect immunity towards pathogenic fungi.
Original languageEnglish
JournalTRENDS IN CELL BIOLOGY
Early online date5 Dec 2020
DOIs
Publication statusE-pub ahead of print - 5 Dec 2020

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