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Programming of neural cells by (endo)cannabinoids: From physiological rules to emerging therapies

Research output: Contribution to journalReview article

Mauro MacCarrone, Manuel Guzmán, Ken MacKie, Patrick Doherty, Tibor Harkany

Original languageEnglish
Pages (from-to)786-801
Number of pages16
JournalNATURE REVIEWS NEUROSCIENCE
Volume15
Issue number12
DOIs
Published11 Dec 2014

King's Authors

Abstract

Among the many signalling lipids, endocannabinoids are increasingly recognized for their important roles in neuronal and glial development. Recent experimental evidence suggests that, during neuronal differentiation, endocannabinoid signalling undergoes a fundamental switch from the prenatal determination of cell fate to the homeostatic regulation of synaptic neurotransmission and bioenergetics in the mature nervous system. These studies also offer novel insights into neuropsychiatric disease mechanisms and contribute to the public debate about the benefits and the risks of cannabis use during pregnancy and in adolescence.

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