Programming of neural cells by (endo)cannabinoids: From physiological rules to emerging therapies

TY - JOUR

T1 - Programming of neural cells by (endo)cannabinoids

T2 - From physiological rules to emerging therapies

AU - MacCarrone, Mauro

AU - Guzmán, Manuel

AU - MacKie, Ken

AU - Doherty, Patrick

AU - Harkany, Tibor

PY - 2014/12/11

Y1 - 2014/12/11

N2 - Among the many signalling lipids, endocannabinoids are increasingly recognized for their important roles in neuronal and glial development. Recent experimental evidence suggests that, during neuronal differentiation, endocannabinoid signalling undergoes a fundamental switch from the prenatal determination of cell fate to the homeostatic regulation of synaptic neurotransmission and bioenergetics in the mature nervous system. These studies also offer novel insights into neuropsychiatric disease mechanisms and contribute to the public debate about the benefits and the risks of cannabis use during pregnancy and in adolescence.

AB - Among the many signalling lipids, endocannabinoids are increasingly recognized for their important roles in neuronal and glial development. Recent experimental evidence suggests that, during neuronal differentiation, endocannabinoid signalling undergoes a fundamental switch from the prenatal determination of cell fate to the homeostatic regulation of synaptic neurotransmission and bioenergetics in the mature nervous system. These studies also offer novel insights into neuropsychiatric disease mechanisms and contribute to the public debate about the benefits and the risks of cannabis use during pregnancy and in adolescence.

UR - http://www.scopus.com/inward/record.url?scp=84917682984&partnerID=8YFLogxK

U2 - 10.1038/nrn3846

DO - 10.1038/nrn3846

M3 - Review article

C2 - 25409697

AN - SCOPUS:84917682984

SN - 1471-003X

VL - 15

SP - 786

EP - 801

JO - NATURE REVIEWS NEUROSCIENCE

JF - NATURE REVIEWS NEUROSCIENCE

IS - 12

ER -