Progressive frontal dysconnectivity during working memory in eos patients: A longitudinal functional MRI study: Abstract of the 25th European Congress of Psychiatry

S. Frangou, M. Kyriakopoulos, D. Danai

    Research output: Contribution to journalMeeting abstractpeer-review

    Abstract

    Working memory (WM) dysfunction is considered a cardinal feature of schizophrenia. Typically developing adolescents show significant gains in WM performance, which have been attributed to increased “frontalisation” within the fronto-cingulate-parietal network that underpins WM. We used functional magnetic resonance imaging and psycho-physiological interaction to measure blood oxygenation level–dependent signal and functional connectivity in response to the 2-back WM task from 25 youths with EOS and 25 yoked healthy adolescents that were assessed twice with a mean interval of 4 years between assessments. Patients showed reduced prefrontal connectivity at baseline and the magnitude of this effect increased over the follow-up period. Our results suggest on-going functional connectivity abnormalities in EOS patients’ post-disease onset that are linked to prefrontal dysfunction and contribute to worsening WM despite anti–psychotic treatment.
    Original languageEnglish
    Pages (from-to)S60
    JournalEuropean Psychiatry
    Volume41, Supplement
    DOIs
    Publication statusE-pub ahead of print - 30 Jun 2017

    Fingerprint

    Dive into the research topics of 'Progressive frontal dysconnectivity during working memory in eos patients: A longitudinal functional MRI study: Abstract of the 25th European Congress of Psychiatry'. Together they form a unique fingerprint.

    Cite this