TY - JOUR
T1 - Progressive Voxelwise Homotopic Connectivity from childhood to adulthood
T2 - Age-related functional asymmetry in resting-state functional magnetic resonance imaging
AU - Tarchi, Livio
AU - Damiani, Stefano
AU - La-Torraca-Vittori, Paolo
AU - Frick, Andreas
AU - Castellini, Giovanni
AU - Politi, Pierluigi
AU - Fusar-Poli, Paolo
AU - Ricca, Valdo
N1 - Funding Information:
This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. Data were obtained from the ADHD200 initiative and OpenfMRI database (https://openfmri.org/dataset/ds000030/). The Authors would like to thank the investigators who shared the NYU and UCLA dataset: X. F. Castellanos, M. P. Milham, A. Di Martino, C. Kelly, M. Mennes, R. Bilder, R. Poldrack, T. Cannon, E. London, N. Freimer, E. Congdon, and K. Karlsgodt.
Publisher Copyright:
© 2023 Wiley Periodicals LLC.
PY - 2023/3
Y1 - 2023/3
N2 - Homotopic connectivity during resting state has been proposed as a risk marker for neurologic and psychiatric conditions, but a precise characterization of its trajectory through development is currently lacking. Voxel-Mirrored Homotopic Connectivity (VMHC) was evaluated in a sample of 85 neurotypical individuals aged 7–18 years. VMHC associations with age, handedness, sex, and motion were explored at the voxel-wise level. VMHC correlates were also explored within 14 functional networks. Primary and secondary outcomes were repeated in a sample of 107 adults aged 21–50 years. In adults, VMHC was negatively correlated with age only in the posterior insula (false discovery rate p <.05, >30-voxel clusters), while a distributed effect among the medial axis was observed in minors. Four out of 14 considered networks showed significant negative correlations between VMHC and age in minors (basal ganglia r = –.280, p =.010; anterior salience r = –.245, p =.024; language r = –.222, p =.041; primary visual r = –.257, p =.017), but not adults. In minors, a positive effect of motion on VMHC was observed only in the putamen. Sex did not significantly influence age effects on VMHC. The current study showed a specific decrease in VMHC for minors as a function of age, but not adults, supporting the notion that interhemispheric interactions can shape late neurodevelopment.
AB - Homotopic connectivity during resting state has been proposed as a risk marker for neurologic and psychiatric conditions, but a precise characterization of its trajectory through development is currently lacking. Voxel-Mirrored Homotopic Connectivity (VMHC) was evaluated in a sample of 85 neurotypical individuals aged 7–18 years. VMHC associations with age, handedness, sex, and motion were explored at the voxel-wise level. VMHC correlates were also explored within 14 functional networks. Primary and secondary outcomes were repeated in a sample of 107 adults aged 21–50 years. In adults, VMHC was negatively correlated with age only in the posterior insula (false discovery rate p <.05, >30-voxel clusters), while a distributed effect among the medial axis was observed in minors. Four out of 14 considered networks showed significant negative correlations between VMHC and age in minors (basal ganglia r = –.280, p =.010; anterior salience r = –.245, p =.024; language r = –.222, p =.041; primary visual r = –.257, p =.017), but not adults. In minors, a positive effect of motion on VMHC was observed only in the putamen. Sex did not significantly influence age effects on VMHC. The current study showed a specific decrease in VMHC for minors as a function of age, but not adults, supporting the notion that interhemispheric interactions can shape late neurodevelopment.
UR - http://www.scopus.com/inward/record.url?scp=85148649779&partnerID=8YFLogxK
U2 - 10.1002/dev.22366
DO - 10.1002/dev.22366
M3 - Article
SN - 0012-1630
VL - 65
JO - Developmental Psychobiology
JF - Developmental Psychobiology
IS - 2
M1 - e22366
ER -