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Progressive Voxelwise Homotopic Connectivity from childhood to adulthood: age-related functional asymmetry in resting state fMRI

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Livio Tarchi, Stefano Damiani, Paolo La-Torraca-Vittori, Andreas Frick, Giovanni Castellini, Pierluigi Politi, Paolo Fusar-Poli, Valdo Ricca

Original languageEnglish
JournalDevelopmental Psychobiology
Accepted/In press2 Dec 2022

King's Authors

Abstract

Homotopic connectivity during resting state has been proposed as a risk marker for neurologic and psychiatric conditions, but a precise characterization of its trajectory through development is currently lacking. Voxel-Mirrored Homotopic Connectivity (VMHC) was evaluated in a sample of 85 neurotypical individuals aged 7-18 years. VMHC associations with age, handedness, sex, and motion were explored at the voxel-wise level. VMHC correlates were also explored within 14 functional networks. Primary and secondary outcomes were repeated in a sample of 107 adults aged 21-50 years. In adults, VMHC was negatively correlated with age only in the posterior insula (false-discovery-rate p30-voxels clusters), while a distributed effect among the medial axis was observed in minors. Four out of 14 considered networks showed significant negative correlations between VMHC and age in minors (basal ganglia r=-0.280 p=0.010, anterior salience r=-0.245 p=0.024, language r=-0.222 p=0.041, primary visual r=-0.257 p=0.017), but not adults. In minors, a positive effect of motion on VMHC was observed only in the putamen. Sex did not significantly influence age effects on VMHC. The current study showed a specific decrease in VMHC for minors as a function of age, but not adults, supporting the notion that interhemispheric interactions can shape late neurodevelopment.

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