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Pro-inflammatory dietary pattern is associated with fractures in women: an eight-year longitudinal cohort study

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Pro-inflammatory dietary pattern is associated with fractures in women : an eight-year longitudinal cohort study. / Veronese, N; Stubbs, Brendon; Koyanagi, A; Hébert, J R; Cooper, C; Caruso, M G; Guglielmi, G; Reginster, J Y; Rizzoli, R; Maggi, S; Shivappa, N.

In: Osteoporosis International, 10.10.2017.

Research output: Contribution to journalArticle

Harvard

Veronese, N, Stubbs, B, Koyanagi, A, Hébert, JR, Cooper, C, Caruso, MG, Guglielmi, G, Reginster, JY, Rizzoli, R, Maggi, S & Shivappa, N 2017, 'Pro-inflammatory dietary pattern is associated with fractures in women: an eight-year longitudinal cohort study', Osteoporosis International. https://doi.org/10.1007/s00198-017-4251-5

APA

Veronese, N., Stubbs, B., Koyanagi, A., Hébert, J. R., Cooper, C., Caruso, M. G., ... Shivappa, N. (2017). Pro-inflammatory dietary pattern is associated with fractures in women: an eight-year longitudinal cohort study. Osteoporosis International. https://doi.org/10.1007/s00198-017-4251-5

Vancouver

Veronese N, Stubbs B, Koyanagi A, Hébert JR, Cooper C, Caruso MG et al. Pro-inflammatory dietary pattern is associated with fractures in women: an eight-year longitudinal cohort study. Osteoporosis International. 2017 Oct 10. https://doi.org/10.1007/s00198-017-4251-5

Author

Veronese, N ; Stubbs, Brendon ; Koyanagi, A ; Hébert, J R ; Cooper, C ; Caruso, M G ; Guglielmi, G ; Reginster, J Y ; Rizzoli, R ; Maggi, S ; Shivappa, N. / Pro-inflammatory dietary pattern is associated with fractures in women : an eight-year longitudinal cohort study. In: Osteoporosis International. 2017.

Bibtex Download

@article{299d843b76d84872b1d316698b19bfcf,
title = "Pro-inflammatory dietary pattern is associated with fractures in women: an eight-year longitudinal cohort study",
abstract = "In this study, during 8 years of follow-up, we reported that higher dietary inflammatory index values were associated with a higher risk of incident fractures in women, but not in men, after adjusting for potential confounders.INTRODUCTION: Inflammation is a key risk factor for many adverse outcomes in older people. While diet is a potential source of inflammation, little is known about the impact of inflammatory diet on fractures. Thus, we investigated whether higher Dietary Inflammatory Index (DII)™ {\circledR} scores are associated with fractures in a cohort of North American people.METHODS: This longitudinal study with a follow-up of 8 years included 3648 participants (1577 males and 2071 females; mean age = 60.6 years) with/at risk of knee osteoarthritis participating with in the Osteoarthritis Initiative. DII scores were calculated using the validated Block Brief 2000 Food Frequency Questionnaire, categorized into sex-specific quintiles. Information on fractures was obtained through self-reported history of fractures at hip, spine, and forearm. The relationship between baseline DII score and incident fracture was assessed through a Cox's regression analysis, adjusted for potential baseline confounders, and reported as hazard ratios (HRs).RESULTS: During 8 years of follow-up, 560 individuals developed fractures (15.4{\%}). Adjusting for 10 potential confounders, women in the highest DII score quintile (i.e., most pro-inflammatory diet) had a significantly higher risk for fractures (HR = 1.46; 95{\%} CI = 1.02-2.11) compared to women in the lowest quintile. An increase in one standard deviation of DII scores significantly predicted fracture onset in women (adjusted HR = 1.14; 95{\%} CI = 1.02-1.27). The association between DII score and fractures was not significant among men or in the sample as whole.CONCLUSION: Pro-inflammatory diet is associated with a higher incidence of fractures in women but not men.",
author = "N Veronese and Brendon Stubbs and A Koyanagi and H{\'e}bert, {J R} and C Cooper and Caruso, {M G} and G Guglielmi and Reginster, {J Y} and R Rizzoli and S Maggi and N Shivappa",
year = "2017",
month = "10",
day = "10",
doi = "10.1007/s00198-017-4251-5",
language = "English",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Pro-inflammatory dietary pattern is associated with fractures in women

T2 - an eight-year longitudinal cohort study

AU - Veronese, N

AU - Stubbs, Brendon

AU - Koyanagi, A

AU - Hébert, J R

AU - Cooper, C

AU - Caruso, M G

AU - Guglielmi, G

AU - Reginster, J Y

AU - Rizzoli, R

AU - Maggi, S

AU - Shivappa, N

PY - 2017/10/10

Y1 - 2017/10/10

N2 - In this study, during 8 years of follow-up, we reported that higher dietary inflammatory index values were associated with a higher risk of incident fractures in women, but not in men, after adjusting for potential confounders.INTRODUCTION: Inflammation is a key risk factor for many adverse outcomes in older people. While diet is a potential source of inflammation, little is known about the impact of inflammatory diet on fractures. Thus, we investigated whether higher Dietary Inflammatory Index (DII)™ ® scores are associated with fractures in a cohort of North American people.METHODS: This longitudinal study with a follow-up of 8 years included 3648 participants (1577 males and 2071 females; mean age = 60.6 years) with/at risk of knee osteoarthritis participating with in the Osteoarthritis Initiative. DII scores were calculated using the validated Block Brief 2000 Food Frequency Questionnaire, categorized into sex-specific quintiles. Information on fractures was obtained through self-reported history of fractures at hip, spine, and forearm. The relationship between baseline DII score and incident fracture was assessed through a Cox's regression analysis, adjusted for potential baseline confounders, and reported as hazard ratios (HRs).RESULTS: During 8 years of follow-up, 560 individuals developed fractures (15.4%). Adjusting for 10 potential confounders, women in the highest DII score quintile (i.e., most pro-inflammatory diet) had a significantly higher risk for fractures (HR = 1.46; 95% CI = 1.02-2.11) compared to women in the lowest quintile. An increase in one standard deviation of DII scores significantly predicted fracture onset in women (adjusted HR = 1.14; 95% CI = 1.02-1.27). The association between DII score and fractures was not significant among men or in the sample as whole.CONCLUSION: Pro-inflammatory diet is associated with a higher incidence of fractures in women but not men.

AB - In this study, during 8 years of follow-up, we reported that higher dietary inflammatory index values were associated with a higher risk of incident fractures in women, but not in men, after adjusting for potential confounders.INTRODUCTION: Inflammation is a key risk factor for many adverse outcomes in older people. While diet is a potential source of inflammation, little is known about the impact of inflammatory diet on fractures. Thus, we investigated whether higher Dietary Inflammatory Index (DII)™ ® scores are associated with fractures in a cohort of North American people.METHODS: This longitudinal study with a follow-up of 8 years included 3648 participants (1577 males and 2071 females; mean age = 60.6 years) with/at risk of knee osteoarthritis participating with in the Osteoarthritis Initiative. DII scores were calculated using the validated Block Brief 2000 Food Frequency Questionnaire, categorized into sex-specific quintiles. Information on fractures was obtained through self-reported history of fractures at hip, spine, and forearm. The relationship between baseline DII score and incident fracture was assessed through a Cox's regression analysis, adjusted for potential baseline confounders, and reported as hazard ratios (HRs).RESULTS: During 8 years of follow-up, 560 individuals developed fractures (15.4%). Adjusting for 10 potential confounders, women in the highest DII score quintile (i.e., most pro-inflammatory diet) had a significantly higher risk for fractures (HR = 1.46; 95% CI = 1.02-2.11) compared to women in the lowest quintile. An increase in one standard deviation of DII scores significantly predicted fracture onset in women (adjusted HR = 1.14; 95% CI = 1.02-1.27). The association between DII score and fractures was not significant among men or in the sample as whole.CONCLUSION: Pro-inflammatory diet is associated with a higher incidence of fractures in women but not men.

U2 - 10.1007/s00198-017-4251-5

DO - 10.1007/s00198-017-4251-5

M3 - Article

C2 - 29018920

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

ER -

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