Prospective identification of CRT super responders using a motion atlas and random projection ensemble learning

Devis Peressutti, Wenjia Bai, Thomas Jackson, Manav Sohal, Christopher Aldo Rinaldi, Daniel Rueckert, Andrew P. King

Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

13 Citations (Scopus)

Abstract

Cardiac Resynchronisation Therapy (CRT) treats patients with heart failure and electrical dyssynchrony. However, many patients do not respond to therapy. We propose a novel framework for the prospective characterisation of CRT ‘super-responders’ based on motion analysis of the Left Ventricle (LV). A spatio-temporal motion atlas for the comparison of the LV motions of different subjects is built using cardiac MR imaging. Patients likely to present a super-response to the therapy are identified using a novel ensemble learning classification method based on random projections of the motion data. Preliminary results on a cohort of 23 patients show a sensitivity and specificity of 70% and 85%.

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
PublisherSpringer‐Verlag Berlin Heidelberg
Pages493-500
Number of pages8
Volume9351
ISBN (Print)9783319245737
DOIs
Publication statusPublished - 2015
Event18th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2015 - Munich, Germany
Duration: 5 Oct 20159 Oct 2015

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9351
ISSN (Print)03029743
ISSN (Electronic)16113349

Conference

Conference18th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2015
Country/TerritoryGermany
CityMunich
Period5/10/20159/10/2015

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