Prospects for COPD treatment

Maria Gabriella Matera, Mario Cazzola*, Clive Page

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Citations (Scopus)

Abstract

The management of chronic obstructive pulmonary disease (COPD) is fundamentally still heavily dependent on the use of bronchodilators and corticosteroids. Therefore, there is a need for alternative, more effective and safer therapeutic approaches. In particular, since inflammation in COPD lungs is often poorly responsive to corticosteroid treatment, novel pharmacological anti-inflammatory approaches are needed to optimally treat COPD patients. There have been multiple attempts to develop drugs that inhibit recruitment and activation of inflammatory cells, such as macrophages, neutrophils and T-lymphocytes, in the lungs of patients with COPD or target inflammatory mediators that are important in the recruitment or activation of these inflammatory cells or released by such cells. This review article focuses on novel classes of anti-inflammatory drugs that have already been tested in humans as possible treatments for patients with COPD.

Original languageEnglish
Pages (from-to)74-84
Number of pages11
JournalCurrent Opinion in Pharmacology
Volume56
DOIs
Publication statusPublished - Feb 2021

Keywords

  • Anti-inflammatory treatment
  • COPD
  • New therapies

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