Prospects for using risk scores in polygenic medicine

Cathryn M. Lewis; Evangelos Vassos

doi:10.1186/s13073-017-0489-y

Prospects for using risk scores in polygenic medicine

Cathryn M. Lewis^*, Evangelos Vassos

^*Corresponding author for this work

Department Medical and Molecular Genetics

Research output: Contribution to journal › Comment/debate › peer-review

124 Citations (Scopus)

202 Downloads (Pure)

Abstract

Genome-wide association studies have made strides in identifying common variation associated with disease. The modest effect sizes preclude risk prediction based on single genetic variants, but polygenic risk scores that combine thousands of variants show some predictive ability across a range of complex traits and diseases, including neuropsychiatric disorders. Here, we consider the potential for translation to clinical use.

Original language	English
Article number	96
Number of pages	3
Journal	Genome medicine
Volume	9
Issue number	1
Early online date	13 Nov 2017
DOIs	https://doi.org/10.1186/s13073-017-0489-y
Publication status	E-pub ahead of print - 13 Nov 2017

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10.1186/s13073-017-0489-yLicence: CC BY

Prospects for using risk_LEWIS_Publishedonline13November2017_GOLD VoR (CC BY)Final published version, 250 KBLicence: CC BY

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AB - Genome-wide association studies have made strides in identifying common variation associated with disease. The modest effect sizes preclude risk prediction based on single genetic variants, but polygenic risk scores that combine thousands of variants show some predictive ability across a range of complex traits and diseases, including neuropsychiatric disorders. Here, we consider the potential for translation to clinical use.

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Prospects for using risk scores in polygenic medicine

Abstract

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