The invention relates to a method for inhibiting an ADAM protease, comprising inhibiting binding to an integrin-binding loop of a disintegrin domain in the ADAM protease. Also provided are cyclic peptides which inhibit binding to an integrin-binding loop of an ADAM protease, as well as associated pharmaceutical compositions, uses and methods of treatment.
|Patent number||USPTO 14/798,825|
|Publication status||Published - 11 Apr 2017|
- chemotherapeutic approaches
- metastatic disease