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Protein aggregates and dementia: is there a common toxicity?

Research output: Contribution to journalLiterature review

Original languageEnglish
Pages (from-to)152 - 161
Number of pages10
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume72
Issue number2
Publication statusPublished - 2002

King's Authors

Abstract

This review considers some of the recent advances made in the understanding of the pathogenic proteins known to aggregate and be implicated in neurodegenerative dementing disorders. It concentrates on the two most obvious candidates for the role of toxic protein in Alzheimer's disease (AD)-beta-amyloid peptide and tau-but also considers other proteins in this disorder and in less common but equally devastating diseases.

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