Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

A Dalrymple; E J Wild; R Joubert; K Sathasivam; M Bjorkqvist; A Petersen; G S Jackson; J D Isaacs; M Kristiansen; G P Bates; B R Leavitt; G Keir; M Ward; S J Tabrizi

doi:10.1021/pr0700753

Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

A Dalrymple, E J Wild, R Joubert, K Sathasivam, M Bjorkqvist, A Petersen, G S Jackson, J D Isaacs, M Kristiansen, G P Bates, B R Leavitt, G Keir, M Ward, S J Tabrizi

Medical & Molecular Genetics

Research output: Contribution to journal › Article › peer-review

194 Citations (Scopus)

Abstract

Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers

Original language	English
Pages (from-to)	2833 - 2840
Number of pages	8
Journal	JOURNAL OF PROTEOME RESEARCH
Volume	6
Issue number	7
DOIs	https://doi.org/10.1021/pr0700753
Publication status	Published - Jul 2007

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Dalrymple, A., Wild, E. J., Joubert, R., Sathasivam, K., Bjorkqvist, M., Petersen, A., Jackson, G. S., Isaacs, J. D., Kristiansen, M., Bates, G. P., Leavitt, B. R., Keir, G., Ward, M., & Tabrizi, S. J. (2007). Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates. JOURNAL OF PROTEOME RESEARCH, 6(7), 2833 - 2840. https://doi.org/10.1021/pr0700753

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abstract = "Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers",

author = "A Dalrymple and Wild, {E J} and R Joubert and K Sathasivam and M Bjorkqvist and A Petersen and Jackson, {G S} and Isaacs, {J D} and M Kristiansen and Bates, {G P} and Leavitt, {B R} and G Keir and M Ward and Tabrizi, {S J}",

year = "2007",

month = jul,

doi = "10.1021/pr0700753",

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Dalrymple, A, Wild, EJ, Joubert, R, Sathasivam, K, Bjorkqvist, M, Petersen, A, Jackson, GS, Isaacs, JD, Kristiansen, M, Bates, GP, Leavitt, BR, Keir, G, Ward, M & Tabrizi, SJ 2007, 'Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates', JOURNAL OF PROTEOME RESEARCH, vol. 6, no. 7, pp. 2833 - 2840. https://doi.org/10.1021/pr0700753

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T1 - Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

AU - Dalrymple, A

AU - Wild, E J

AU - Joubert, R

AU - Sathasivam, K

AU - Bjorkqvist, M

AU - Petersen, A

AU - Jackson, G S

AU - Isaacs, J D

AU - Kristiansen, M

AU - Bates, G P

AU - Leavitt, B R

AU - Keir, G

AU - Ward, M

AU - Tabrizi, S J

PY - 2007/7

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N2 - Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers

AB - Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers

U2 - 10.1021/pr0700753

DO - 10.1021/pr0700753

M3 - Article

VL - 6

SP - 2833

EP - 2840

JO - JOURNAL OF PROTEOME RESEARCH

JF - JOURNAL OF PROTEOME RESEARCH

IS - 7

ER -

Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

Abstract

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