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Proteomics of Alzheimer's disease: understanding mechanisms and seeking biomarkers

Research output: Contribution to journalLiterature review

S Lovestone, A Guntert, A Hye, S Lynham, M Thambisetty, M Ward

Original languageEnglish
Pages (from-to)227 - 238
Number of pages12
JournalEXPERT REVIEW OF PROTEOMICS
Volume4
Issue number2
DOIs
Publication statusPublished - Apr 2007

King's Authors

Abstract

Alzheimer's disease is the scourge of the modern, aging world: a costly, damaging disease that robs the elderly of their ability to function as well as their memories. Three decades of progress have resulted in a deep understanding of the pathological processes and a range of targets for therapy, many of which have advanced to late-stage-clinical trials. Proteomics has contributed greatly to these advances and will continue to have a growing role in determining the nature of the pathological lesions in the brain. In addition, proteomics (both gel based and gel free, mass spectrometry based), is likely to play an increasing role in identifying biomarkers that may assist in early diagnosis and in monitoring progression and, most importantly, response to therapy

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