Proton Magnetic Resonance Spectroscopy of the Striatum in Parkinson's Disease Patients with Motor Response Fluctuations

Kallol Ray Chaudhuri; G M Lemmens; S C R Williams; C Ellis; C M Lloyd; J Dawson; A Simmons; P N Leigh

doi:10.1016/1353-8020(96)00007-7

Proton Magnetic Resonance Spectroscopy of the Striatum in Parkinson's Disease Patients with Motor Response Fluctuations

Kallol Ray Chaudhuri^*, G M Lemmens, S C R Williams, C Ellis, C M Lloyd, J Dawson, A Simmons, P N Leigh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

We have performed proton magnetic resonance spectroscopy centred on the putamen contralateral to the worst affected side in 10 patients with idiopathic Parkinson's disease (PD) and motor response fluctuations and seven age matched healthy controls. In PD, there was striking reduction in the N-acetylaspartate (NAA) and creatine and NAA/choline ratios compared to controls. This pilot study provides in vivo evidence of striatal neuronal dysfunction in PD and further studies are in progress to establish if the observed changes are due to the disease process itself or due to chronic levodopa therapy. Copyright © 1996 Published by Elsevier Science Ltd.

Original language	English
Pages (from-to)	63-67
Number of pages	5
Journal	Parkinsonism & Related Disorders
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/1353-8020(96)00007-7
Publication status	Published - 1 Apr 1996

Keywords

Magnetic resonance spectroscopy
Parkinson's disease
Putamen

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10.1016/1353-8020(96)00007-7

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abstract = "We have performed proton magnetic resonance spectroscopy centred on the putamen contralateral to the worst affected side in 10 patients with idiopathic Parkinson's disease (PD) and motor response fluctuations and seven age matched healthy controls. In PD, there was striking reduction in the N-acetylaspartate (NAA) and creatine and NAA/choline ratios compared to controls. This pilot study provides in vivo evidence of striatal neuronal dysfunction in PD and further studies are in progress to establish if the observed changes are due to the disease process itself or due to chronic levodopa therapy. Copyright {\textcopyright} 1996 Published by Elsevier Science Ltd.",

keywords = "Magnetic resonance spectroscopy, Parkinson's disease, Putamen",

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AU - Ray Chaudhuri, Kallol

AU - Lemmens, G M

AU - Williams, S C R

AU - Ellis, C

AU - Lloyd, C M

AU - Dawson, J

AU - Simmons, A

AU - Leigh, P N

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AB - We have performed proton magnetic resonance spectroscopy centred on the putamen contralateral to the worst affected side in 10 patients with idiopathic Parkinson's disease (PD) and motor response fluctuations and seven age matched healthy controls. In PD, there was striking reduction in the N-acetylaspartate (NAA) and creatine and NAA/choline ratios compared to controls. This pilot study provides in vivo evidence of striatal neuronal dysfunction in PD and further studies are in progress to establish if the observed changes are due to the disease process itself or due to chronic levodopa therapy. Copyright © 1996 Published by Elsevier Science Ltd.

KW - Magnetic resonance spectroscopy

KW - Parkinson's disease

KW - Putamen

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ER -

Proton Magnetic Resonance Spectroscopy of the Striatum in Parkinson's Disease Patients with Motor Response Fluctuations

Abstract

Keywords

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