Psoriasis and Genetics

Nick Dand; Satveer K Mahil; Francesca Capon; Catherine H Smith; Michael A Simpson; Jonathan N Barker

doi:10.2340/00015555-3384

Psoriasis and Genetics

Nick Dand, Satveer K Mahil, Francesca Capon, Catherine H Smith, Michael A Simpson, Jonathan N Barker

Research output: Contribution to journal › Review article › peer-review

71 Citations (Scopus)

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Abstract

Psoriasis is a common inflammatory skin disease caused by the interplay between multiple genetic and environmental risk factors. This review summarises recent progress in elucidating the genetic basis of psoriasis, particularly through large genome-wide association studies. We illustrate the power of genetic analyses for disease stratification. Psoriasis can be stratified by phenotype (common plaque versus rare pustular variants), or by outcome (prognosis, comorbidities, response to treatment); recent progress has been made in delineating the genetic contribution in each of these areas. We also highlight how genetic data can directly inform the development of effective psoriasis treatments.

Original language	English
Article number	adv00030
Pages (from-to)	54-64
Number of pages	11
Journal	Acta Dermato-Venereologica
Volume	100
Issue number	100-year theme: Psoriasis
Early online date	23 Jan 2020
DOIs	https://doi.org/10.2340/00015555-3384
Publication status	Published - 30 Jan 2020

Keywords

disease progression
genetics
precision medicine
psoriasis
treatment outcome

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10.2340/00015555-3384Licence: CC BY-NC

Psoriasis and Genetics_DAND_Publishedonline23January2020_GOLD VoR (CC BY-NC)Final published version, 1.27 MBLicence: CC BY-NC

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AU - Mahil, Satveer K

AU - Capon, Francesca

AU - Smith, Catherine H

AU - Simpson, Michael A

AU - Barker, Jonathan N

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AB - Psoriasis is a common inflammatory skin disease caused by the interplay between multiple genetic and environmental risk factors. This review summarises recent progress in elucidating the genetic basis of psoriasis, particularly through large genome-wide association studies. We illustrate the power of genetic analyses for disease stratification. Psoriasis can be stratified by phenotype (common plaque versus rare pustular variants), or by outcome (prognosis, comorbidities, response to treatment); recent progress has been made in delineating the genetic contribution in each of these areas. We also highlight how genetic data can directly inform the development of effective psoriasis treatments.

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KW - treatment outcome

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Psoriasis and Genetics

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