Research output: Contribution to journal › Review article › peer-review
Nick Dand, Satveer K Mahil, Francesca Capon, Catherine H Smith, Michael A Simpson, Jonathan N Barker
Original language | English |
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Article number | adv00030 |
Pages (from-to) | 54-64 |
Number of pages | 11 |
Journal | Acta Dermato-Venereologica |
Volume | 100 |
Issue number | 100-year theme: Psoriasis |
Early online date | 23 Jan 2020 |
DOIs | |
Accepted/In press | 28 Nov 2019 |
E-pub ahead of print | 23 Jan 2020 |
Published | 30 Jan 2020 |
Additional links |
Psoriasis and Genetics_DAND_Publishedonline23January2020_GOLD VoR (CC BY-NC)
Psoriasis_and_Genetics_DAND_Publishedonline23January2020_GOLD_VoR_CC_BY_NC_.pdf, 1.27 MB, application/pdf
Uploaded date:18 Feb 2020
Version:Final published version
Licence:CC BY-NC
Psoriasis is a common inflammatory skin disease caused by the interplay between multiple genetic and environmental risk factors. This review summarises recent progress in elucidating the genetic basis of psoriasis, particularly through large genome-wide association studies. We illustrate the power of genetic analyses for disease stratification. Psoriasis can be stratified by phenotype (common plaque versus rare pustular variants), or by outcome (prognosis, comorbidities, response to treatment); recent progress has been made in delineating the genetic contribution in each of these areas. We also highlight how genetic data can directly inform the development of effective psoriasis treatments.
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